Cardioprotective effect of preconditioning is more efficient than postconditioning in rats submitted to cardiac ischemia and reperfusion
Acta cir. bras
;
33(7): 588-596, July 2018. graf
Article
in English
| LILACS
| ID: biblio-949370
ABSTRACT
Abstract Purpose:
To investigate the cardioprotective effects of ischemic preconditioning (preIC) and postconditioning (postIC) in animal model of cardiac ischemia/reperfusion.Methods:
Adult rats were submitted to protocol of cardiac ischemia/reperfusion (I/R) and randomized into three experimental groups cardiac I/R (n=33), preCI + cardiac I/R (n=7) and postCI + cardiac I/R (n=8). After this I/R protocol, the incidence of ventricular arrhythmia (VA), atrioventricular block (AVB) and lethality (LET) was evaluated using the electrocardiogram (ECG) analysis.Results:
After reestablishment of coronary blood flow, we observed variations of the ECG trace with increased incidence of ventricular arrhythmia (VA) (85%), atrioventricular block (AVB) (79%), and increase of lethality (70%) in cardiac I/R group. The comparison between I/R + preIC group with I/R group demonstrated significant reduction in VA incidence to 28%, AVB to 0% and lethality to 14%. The comparison of I/R + postIC group with I/R group was observed significance reduction in AVB incidence to 25% and lethality to 25%.Conclusion:
The preconditioning strategies produce cardioprotection more efficient that postconditioning against myocardial dysfunctions and lethality by cardiac ischemia and reperfusion.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Myocardial Reperfusion Injury
/
Ischemic Preconditioning, Myocardial
/
Ischemic Postconditioning
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Medicina do ABC/BR
/
UNIFESP/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Nove de Julho/BR
/
Universidade de São Paulo/BR
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