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Correlations of inhaled NO with the cTnI levels and the plasma clotting factor in rabbits with acute massive pulmonary embolism
Zhang, Zeming; Meng, Zibo; Wang, Yancun.
  • Zhang, Zeming; Shanghai Health Medical College. Affiliated Zhou Pu Hospital. Department of Respiratory Medicine. CN
  • Meng, Zibo; Hebei University. Affiliated Hospital. Department of Respiration. Baoding. CN
  • Wang, Yancun; Shanghai Health Medical College. Affiliated Zhou Pu Hospital. Department of Nerve. CN
Acta cir. bras ; 33(8): 664-672, Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-949374
ABSTRACT
Abstract

Purpose:

To investigate the correlation of inhaled nitric oxide (NO) on plasma levels of cardiac troponin I (cTnI) and von Willebrand factor (vWF), glycoprotein (GP) IIb/IIIa, granule membrane protein 140 (GMP-140) in rabbits with acute massive pulmonary embolism (PE).

Methods:

Thirty apanese white rabbits were divided into 3 groups, thrombus were injected in model group (n = 10), NO were inhalated for 24 h after massive PE in NO group (n = 10), saline were injected in control group (n = 10). The concentrations of vWF, GP IIb/IIIa, GMP-140 and cTnI were tested at 4, 8, 12, 16, 20, and 24 h, Correlation analyses were conducted between cTnI and vWF, GP IIb/IIIa, and GMP-140 by Pearson's correlation.

Results:

The concentration of cTnI and vWF, GP IIb/IIIa, and GMP-140 was increased in the model group, compared to control group. In the inhaled group, the concentrations of cTnI, vWF, GP IIb/IIIa, and GMP-140 were reduced compared to model group. There was a positive correlation between cTnI and vWF, GP IIb/IIIa, and GMP-140.

Conclusion:

Inhaled nitric oxide can lead to a decrease in levels of cardiac troponin I, von Willebrand factor, glycoprotein, and granule membrane protein 140, after an established myocardial damage, provoked by acute massive pulmonary embolism.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pulmonary Embolism / Von Willebrand Factor / Platelet Glycoprotein GPIIb-IIIa Complex / P-Selectin / Troponin I / Nitric Oxide Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Hebei University/CN / Shanghai Health Medical College/CN

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Full text: Available Index: LILACS (Americas) Main subject: Pulmonary Embolism / Von Willebrand Factor / Platelet Glycoprotein GPIIb-IIIa Complex / P-Selectin / Troponin I / Nitric Oxide Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Hebei University/CN / Shanghai Health Medical College/CN