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Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
Ortolani Jr, Pedro D; Romaldini, João H; Guerra, Ricardo A; Portes, Evandro S; Meireles, George C X; Pimenta, João.
  • Ortolani Jr, Pedro D; Instituto de Assistência Médica ao Servidor Público Estadual. Hospital do Servidor Público Estadual de São Paulo. Serviço de Endocrinologia. São Paulo. BR
  • Romaldini, João H; Instituto de Assistência Médica ao Servidor Público Estadual. Hospital do Servidor Público Estadual de São Paulo. Serviço de Endocrinologia. São Paulo. BR
  • Guerra, Ricardo A; Instituto de Assistência Médica ao Servidor Público Estadual. Hospital do Servidor Público Estadual de São Paulo. Serviço de Endocrinologia. São Paulo. BR
  • Portes, Evandro S; Instituto de Assistência Médica ao Servidor Público Estadual. Hospital do Servidor Público Estadual de São Paulo. Serviço de Endocrinologia. São Paulo. BR
  • Meireles, George C X; Instituto de Assistência Médica ao Servidor Público Estadual. Hospital do Servidor Público Estadual de São Paulo. Serviço de Cardiologia. São Paulo. BR
  • Pimenta, João; Instituto de Assistência Médica ao Servidor Público Estadual. Hospital do Servidor Público Estadual de São Paulo. Serviço de Cardiologia. São Paulo. BR
Arch. endocrinol. metab. (Online) ; 62(4): 410-415, July-Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-950086
ABSTRACT
ABSTRACT

Objective:

The association between coronary artery disease (CAD) and thyroid function remains controversial. We evaluated the thyroid function and graduated well-defined CAD as confirmed by quantitative coronary angiography (CA). Subjects and

methods:

We evaluated the serum TSH, free thyroxine, free triiodothyronine and thyroid antibody levels in 300 consecutive patients (age 61.6 ± 9.9 years and 54% were male) undergoing CAD diagnosis as confirmed by CA. Plaques with ≥ 50% stenosis being indicative of obstructive CAD, and patients were divided into groups according to main epicardial coronary arteries with plaques (0, 1, 2, 3). Lipid profiles and a homeostasis model assessment (HOMA-IR) were determined.

Results:

Serum median (25% and 75% percentile) TSH levels in patients with group 2 and 3 (2.25; 1.66-3.12 mU/L and 4.99; 4.38-23.60 mU/L, respectively) had significantly higher TSH concentrations (p < 0.0001) than the group 0 (1.82; 1.35-2.51 mU/L). Furthermore, patients of group 3 had higher TSH concentration (p < 0.0001) than those of group 1 (1.60; 0.89-2.68 mU/L). Group 3 were older (64 ± 8.5 vs. 59 ± 9.5, p = 0.001), had more patients with dyslipidemia (84% versus 58%, p < 0.001), male (54% versus 44%, p = 0.01), hypertension (100% versus 86%, p < 0.001), and smoking (61% versus 33%, p < 0.001) than group 0. Multivariate stepwise logistic analysis showed TSH, age, HbA1c, and HOMA-IR were the CAD associated variables.

Conclusions:

In this cohort, elevated TSH levels in the high normal range or above are associated with the presence and severity of CAD besides may represent a weak CAD risk factor.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Coronary Artery Disease / Thyrotropin Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Aged / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto de Assistência Médica ao Servidor Público Estadual/BR

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Full text: Available Index: LILACS (Americas) Main subject: Coronary Artery Disease / Thyrotropin Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Aged / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto de Assistência Médica ao Servidor Público Estadual/BR