Your browser doesn't support javascript.
loading
Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis
Khanizadeh, Fatemeh; Rahmani, Asghar; Asadollahi, Khairollah; Ahmadi, Mohammad Reza Hafezi.
  • Khanizadeh, Fatemeh; Shahid Beheshti University of Medical Science. Tehran. IR
  • Rahmani, Asghar; Ilam University of Medical Science. Ilam. IR
  • Asadollahi, Khairollah; Ilam University of Medical Sciences. Faculty of Medicine. Departament of Social Medicine. Ilam. IR
  • Ahmadi, Mohammad Reza Hafezi; Ilam University of Medical Science. Department of Pathology. Ilam. IR
Arch. endocrinol. metab. (Online) ; 62(4): 438-445, July-Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-950087
ABSTRACT
ABSTRACT

Objective:

This study evaluated the effects of combination therapy of curcumin and alendronate on BMD and bone turnover markers in postmenopausal women with osteoporosis. Subjects and

methods:

In a randomized, double-blind trial study, 60 postmenopausal women were divided into three groups control, alendronate, and alendronate + curcumin. Each group included 20 patients. Total body, total hip, lumbar spine and femoral neck BMDs were measured by dual-energy X-ray absorptiometry (DXA) at baseline and after 12 months of therapy. Bone turnover markers such as bone-specific alkaline phosphatase (BALP), osteocalcin and C-terminal cross-linking telopeptide of type I collagen (CTx) were measured at the outset and 6 months later.

Results:

Patients in the control group suffered a significant decrease in BMD and increased bone turnover markers at the end of study. The group treated with only alendronate showed significantly decreased levels of BALP and CTx and increased levels of osteocalcin compared to the control group. The alendronate group also showed significant increases in the total body, total hip, lumbar spine and femoral neck BMDs at the end of study compared to the control group. In the curcumin + alendronate group, BALP and CTx levels decreased and osteocalcin levels increased significantly at the end of study compared to the control and alendronate groups. BMD indexes also increased in four areas significantly at the end of study compared to the control and alendronate groups.

Conclusion:

The combination of curcumin and alendronate has beneficial effects on BMD and bone turnover markers among postmenopausal women with osteoporosis. Arch Endocrinol Metab. 2018;62(4)438-45
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bone Density / Osteoporosis, Postmenopausal / Alendronate / Curcumin / Bone Density Conservation Agents Type of study: Controlled clinical trial Limits: Aged / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2018 Type: Article Affiliation country: Iran Institution/Affiliation country: Ilam University of Medical Science/IR / Ilam University of Medical Sciences/IR / Shahid Beheshti University of Medical Science/IR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Bone Density / Osteoporosis, Postmenopausal / Alendronate / Curcumin / Bone Density Conservation Agents Type of study: Controlled clinical trial Limits: Aged / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2018 Type: Article Affiliation country: Iran Institution/Affiliation country: Ilam University of Medical Science/IR / Ilam University of Medical Sciences/IR / Shahid Beheshti University of Medical Science/IR