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Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
Promphet, Porkaew; Bunarsa, Sirirat; Sutheerawattananonda, Manote; Kunthalert, Duangkamol.
  • Promphet, Porkaew; Naresuan University. Faculty of Science. Department of Biology. Phitsanulok. TH
  • Bunarsa, Sirirat; Naresuan University. Faculty of Medical Science. Department of Microbiology and Parasitology. Phitsanulok. TH
  • Sutheerawattananonda, Manote; Suranaree University of Technology. Institute of Agricultural Technology. School of Food Technology. Nakhon Ratchasima. TH
  • Kunthalert, Duangkamol; Naresuan University. Faculty of Medical Science. Department of Microbiology and Parasitology. Phitsanulok. TH
Biol. Res ; 47: 1-10, 2014. graf, tab
Article in English | LILACS | ID: biblio-950711
ABSTRACT

BACKGROUND:

Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant source of lutein, and this unexplored silk extract could be a viable alternative source for dietary lutein. This study assessed immunomodulatory activities of the silk lutein extract. Female BALB/c mice orally received lutein, either as silk or marigold extracts (10 or 20 mg/kg daily), or vehicle only (1% tween 80 in PBS pH 7.4) for 4 weeks. Natural killer (NK) cell activity, specific antibody production, lymphocyte subpopulations, mitogen-induced lymphocyte proliferation, and cytokine production were examined.

RESULTS:

Silk lutein extract increased NK cell activity, and the effect was dose-related whereas marigold lutein extract was ineffective. Silk lutein extract dose-dependently enhanced antibody production in pre-immunized mice but marigold lutein extract had no effect. Feeding with silk lutein extract increased the populations of CD3+ and CD4 + CD3 + cells. Silk lutein extract also stimulated concanavalin A- and lipopolysaccharide-induced proliferations of T and B lymphocytes, respectively. Moreover, silk lutein extract increased IL-2 and IFN-γ production while the effect of marigold lutein extract was undetectable.

CONCLUSIONS:

Together, silk lutein extract enhanced both innate and adaptive immune functions. This preparation may prove to be an effective supplement for strengthened immunity.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bombyx / Tissue Extracts / Lutein / Silk / Animal Shells / Immunologic Factors Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2014 Type: Article Affiliation country: Thailand Institution/Affiliation country: Naresuan University/TH / Suranaree University of Technology/TH

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Full text: Available Index: LILACS (Americas) Main subject: Bombyx / Tissue Extracts / Lutein / Silk / Animal Shells / Immunologic Factors Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2014 Type: Article Affiliation country: Thailand Institution/Affiliation country: Naresuan University/TH / Suranaree University of Technology/TH