Immune enhancement activities of silk lutein extract from Bombyx mori cocoons
Biol. Res
;
47: 1-10, 2014. graf, tab
Article
in English
| LILACS
| ID: biblio-950711
ABSTRACT
BACKGROUND:
Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant source of lutein, and this unexplored silk extract could be a viable alternative source for dietary lutein. This study assessed immunomodulatory activities of the silk lutein extract. Female BALB/c mice orally received lutein, either as silk or marigold extracts (10 or 20 mg/kg daily), or vehicle only (1% tween 80 in PBS pH 7.4) for 4 weeks. Natural killer (NK) cell activity, specific antibody production, lymphocyte subpopulations, mitogen-induced lymphocyte proliferation, and cytokine production were examined.RESULTS:
Silk lutein extract increased NK cell activity, and the effect was dose-related whereas marigold lutein extract was ineffective. Silk lutein extract dose-dependently enhanced antibody production in pre-immunized mice but marigold lutein extract had no effect. Feeding with silk lutein extract increased the populations of CD3+ and CD4 + CD3 + cells. Silk lutein extract also stimulated concanavalin A- and lipopolysaccharide-induced proliferations of T and B lymphocytes, respectively. Moreover, silk lutein extract increased IL-2 and IFN-γ production while the effect of marigold lutein extract was undetectable.CONCLUSIONS:
Together, silk lutein extract enhanced both innate and adaptive immune functions. This preparation may prove to be an effective supplement for strengthened immunity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bombyx
/
Tissue Extracts
/
Lutein
/
Silk
/
Animal Shells
/
Immunologic Factors
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2014
Type:
Article
Affiliation country:
Thailand
Institution/Affiliation country:
Naresuan University/TH
/
Suranaree University of Technology/TH
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