Your browser doesn't support javascript.
loading
Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
Moreira, Priscila R; Maioli, Marcos A; Medeiros, Hyllana CD; Guelfi, Marieli; Pereira, Flávia TV; Mingatto, Fábio E.
  • Moreira, Priscila R; Univ Estadual Paulista. Laboratório de Bioquímica Metabólica e Toxicológica. Dracena. BR
  • Maioli, Marcos A; Univ Estadual Paulista. Laboratório de Bioquímica Metabólica e Toxicológica. Dracena. BR
  • Medeiros, Hyllana CD; Univ Estadual Paulista. Laboratório de Bioquímica Metabólica e Toxicológica. Dracena. BR
  • Guelfi, Marieli; Univ Estadual Paulista. Laboratório de Bioquímica Metabólica e Toxicológica. Dracena. BR
  • Pereira, Flávia TV; Univ Estadual Paulista. Laboratório de Morfologia da Placenta e Embrião. Dracena. BR
  • Mingatto, Fábio E; Univ Estadual Paulista. Laboratório de Bioquímica Metabólica e Toxicológica. Dracena. BR
Biol. Res ; 47: 1-7, 2014. ilus, graf
Article in English | LILACS | ID: biblio-950745
ABSTRACT

BACKGROUND:

The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats.

RESULTS:

The animals were divided into four groups with six rats in each group. CCl4 (0.125 mL kg-1 body wt.) was injected intraperitoneally, and bixin (5.0 mg kg-1 body wt.) was given by gavage 7 days before the CCl4 injection. Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release. Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH. The peroxidation of membrane lipids and histopathological damage of the liver was significantly prevented by bixin treatment.

CONCLUSION:

Therefore, we can conclude that the protective effect of bixin against hepatotoxicity induced by CCl4 is related to the antioxidant activity of the compound.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carbon Tetrachloride / Carotenoids / Reactive Oxygen Species / Oxidative Stress / Chemical and Drug Induced Liver Injury / Antioxidants Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Univ Estadual Paulista/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Carbon Tetrachloride / Carotenoids / Reactive Oxygen Species / Oxidative Stress / Chemical and Drug Induced Liver Injury / Antioxidants Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Univ Estadual Paulista/BR