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Mitochondrial ATPase activity and membrane fluidity changes in rat liver in response to intoxication with Buckthorn (Karwinskia humboldtiana)
Cid-Hernández, Margarita; Ramírez-Anguiano, Ana C; Ortiz, Genaro G; Morales-Sanchez, Eddic W; González-Ortiz, Luis J; Velasco-Ramírez, Sandra F; Pacheco-Moisés, Fermín P.
  • Cid-Hernández, Margarita; Universidad de Guadalajara. Centro Universitario de Ciencias Exactas e Ingenierías. Departamento de Química. Guadalajara. MX
  • Ramírez-Anguiano, Ana C; Universidad de Guadalajara. Centro Universitario de Ciencias Exactas e Ingenierías. Departamento de Química. Guadalajara. MX
  • Ortiz, Genaro G; Instituto Mexicano del Seguro Social. Centro de Investigación Biomédica de Occidente. Laboratorio de Desarrollo, Envejecimiento y Enfermedades Neurodegenerativas. División de Neurociencias. Guadalajara. MX
  • Morales-Sanchez, Eddic W; Instituto Mexicano del Seguro Social. Centro de Investigación Biomédica de Occidente. Laboratorio de Desarrollo, Envejecimiento y Enfermedades Neurodegenerativas. División de Neurociencias. Guadalajara. MX
  • González-Ortiz, Luis J; Universidad de Guadalajara. Centro Universitario de Ciencias Exactas e Ingenierías. Departamento de Química. Guadalajara. MX
  • Velasco-Ramírez, Sandra F; Universidad de Guadalajara. Centro Universitario de Ciencias Exactas e Ingenierías. Departamento de Química. Guadalajara. MX
  • Pacheco-Moisés, Fermín P; Universidad de Guadalajara. Centro Universitario de Ciencias Exactas e Ingenierías. Departamento de Química. Guadalajara. MX
Biol. Res ; 48: 1-6, 2015. graf
Article in English | LILACS | ID: biblio-950781
ABSTRACT

BACKGROUND:

Karwinskia humboldtiana (Kh) is a poisonous plant of the rhamnacea family. To elucidate some of the subcellular effects of Kh toxicity, membrane fluidity and ATPase activities as hydrolytic and as proton-pumping activity were assessed in rat liver submitochondrial particles. Rats were randomly assigned into control non-treated group and groups that received 1,1.5 and 2 g/Kg body weight of dry powder of Kh fruit, respectively. Rats were euthanized at day 1 and 7 after treatment.

RESULTS:

Rats under Kh treatment at all dose levels tested, does not developed any neurologic symptoms. However, we detected alterations in membrane fluidity and ATPase activity. Lower dose of Kh on day 1 after treatment induced higher mitochondrial membrane fluidity than control group. This change was strongly correlated with increased ATPase activity and pH gradient driven by ATP hydrolysis. On the other hand, membrane fluidity was hardly affected on day 7 after treatment with Kh. Surprisingly, the pH gradient driven by ATPase activity was significantly higher than controls despite an diminution of the hydrolytic activity of ATPase.

CONCLUSIONS:

The changes in ATPase activity and pH gradient driven by ATPase activity suggest an adaptive condition whereby the fluidity of the membrane is altered.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Mitochondria, Liver / Adenosine Triphosphatases / Karwinskia / Membrane Fluidity Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2015 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Mexicano del Seguro Social/MX / Universidad de Guadalajara/MX

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Full text: Available Index: LILACS (Americas) Main subject: Mitochondria, Liver / Adenosine Triphosphatases / Karwinskia / Membrane Fluidity Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2015 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Mexicano del Seguro Social/MX / Universidad de Guadalajara/MX