TGF-ß1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
Biol. Res
;
48: 1-5, 2015. ilus, graf, tab
Article
in English
| LILACS
| ID: biblio-950790
ABSTRACT
BACKGROUND:
Transforming growth factor (TGF)-ß is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-ß1) expression and prognosis in intrahepatic cholangiocarcinomaRESULTS:
We examined the expression of TGF-ß1 in 78 intrahepatic cholangiocarcinomas by immunohistochemistry and correlated the expression with clinicopathological parameters. TGF-ß1 was expressed in 37 of 78 (47.4 %) intrahepatic cholangiocarcinomas. The expression of TGF-ß1 was significantly correlated with lymph node metastasis, distant metastasis, and tumour recurrence. Patients with TGF-ß1-positive tumours had significantly shorter survival time. In a multivariant analysis, the expression of TGF-ß1 and the tumour stage were independent prognostic factorsCONCLUSIONS:
Our data suggest that expression of TGF-ß1 is a novel prognostic marker for intrahepatic cholangiocarcinoma.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cholangiocarcinoma
/
Transforming Growth Factor beta1
/
Liver Neoplasms
/
Neoplasm Proteins
Type of study:
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2015
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
180th Hospital of People's Liberation Army/CN
/
Eighth People's Hospital of Qingdao/CN
/
Tianjin Medical University General Hospital/CN
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