CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
Biol. Res
;
48: 1-8, 2015. ilus, graf, tab
Article
in English
| LILACS
| ID: biblio-950805
ABSTRACT
BACKGROUND:
CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable.RESULTS:
We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD.CONCLUSIONS:
Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Thymectomy
/
CD4-Positive T-Lymphocytes
/
Hematopoietic Stem Cell Transplantation
/
Graft vs Host Disease
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2015
Type:
Article
Affiliation country:
Japan
Institution/Affiliation country:
Fukushima Medical University/JP
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