Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma
Biol. Res
;
48: 1-8, 2015. ilus, graf, tab
Article
in English
| LILACS
| ID: biblio-950811
ABSTRACT
BACKGROUND:
Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV).RESULTS:
A higher burden of the CNVs was found in 10-50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response [e.g. complement factor H (CFH) and Fc fragment of IgG, low affinity Ilia, receptor (FCGR3A)], starch and sucrose metabolism [e.g. amylase alpha 2A (AMY2A)]. Furthermore, 38 TFs were screened for the 9 CNV-driven genes and then the regulatory network was constructed, in which the GATA-binding factor 1, 2, and 3 (GATA 1, GATA2, GATA3) jointly regulated the expression of TP63.CONCLUSIONS:
The above CNV-driven genes might be potential contributors to the development of lung SCC.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Carcinoma, Squamous Cell
/
Gene Expression Regulation, Neoplastic
/
DNA Copy Number Variations
/
Lung Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2015
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Huazhong University of Science and Technology/CN
/
Ningxia People's Hospital/CN
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