Genetic variants associated with neurodegenerative Alzheimer disease in natural models
Biol. Res
; 49: 1-9, 2016. graf, tab
Article
in En
| LILACS
| ID: biblio-950841
Responsible library:
CL1.1
ABSTRACT
The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
Key words
Full text:
1
Index:
LILACS
Main subject:
Genetic Variation
/
Disease Models, Animal
/
Alzheimer Disease
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Biol. Res
Journal subject:
BIOLOGIA
Year:
2016
Type:
Article