Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
Biol. Res
;
49: 1-9, 2016. ilus, graf
Article
in English
| LILACS
| ID: biblio-950859
ABSTRACT
BACKGROUND:
Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literatureRESULTS:
In this study, we used chitosan-coated levodopa liposomes to investigate the behavioral character and the expression of phosphorylated extracellular signal-regulated kinase (ERK1/2), dopamine- and cAMP-regulated phos-phoprotein of 32 kDa (DARPP-32) and FosB/AFosB in striatum of rat model of levodopa-induced dyskinesia (LID). We found that scores of abnormal involuntary movement (AIM) decreased significantly in liposome group (P < 0.05), compared with levodopa group. Levels of phospho-ERK1/2, phospho-Thr34 DARPP-32 and FosB/AFosB in striatum decreased significantly in liposome group lesion side compared with levodopa group (P < 0.05). However, both of two groups above have significantly differences compared with the control group (P < 0.05).CONCLUSION:
Chitosan-coated levodopa liposomes may be useful in reducing dyskinesias inducing for Parkinson disease. The mechanism might be involved the pathway of signaling molecular phospho-ERK1/2, phospho-Thr34 DARPP-32 and AFosB in striatum
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Dopamine Agents
/
Levodopa
/
Proto-Oncogene Proteins c-fos
/
Chitosan
/
Dyskinesia, Drug-Induced
/
Dopamine and cAMP-Regulated Phosphoprotein 32
Type of study:
Etiology study
/
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2016
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
China Pharmaceutical University/CN
/
Guangdong Pharmaceutical University/CN
/
Huazhong University of Science and Technology/CN
/
Weifang People's Hospital/CN
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