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Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
Mamun, Md. Abdullah Al; Hosen, Mohammad Jakir; Khatun, Amina; Alam, M. Masihul; Al-Bari, Md. Abdul Alim.
  • Mamun, Md. Abdullah Al; Shahjalal University of Science and Technology. Department of Genetic Engineering and Biotechnology. BD
  • Hosen, Mohammad Jakir; Shahjalal University of Science and Technology. Department of Genetic Engineering and Biotechnology. BD
  • Khatun, Amina; Shahjalal University of Science and Technology. Department of Anthropology. BD
  • Alam, M. Masihul; Islami University. Department of Applied Nutrition and Food Technology. BD
  • Al-Bari, Md. Abdul Alim; Rajshahi University. Department of Pharmacy. BD
Biol. Res ; 50: 28, 2017. tab, graf
Article in English | LILACS | ID: biblio-950879
ABSTRACT

BACKGROUND:

The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation and bone resorption. The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. However, the effects of the TPF on in vivo bone formation remain unclear. In this study, we investigated the effects of the TPF on in vivo bone formation, injected the TPF (20 mg/kg) twice a day in the low calcium diet mice and killed them after 21 day. Radiographic and histomorphometric analyses were performed on the dissected bones to determine the anabolic effects of the TPF.

RESULTS:

Bone mineral density and bone mineral content of the TPF-treated mice were significantly increased compared to the control mice. Bone formation-related indices like osteoblast number, osteoblast surface, bone volume, mineralizing surface, mineral apposition rate and bone formation rate were significantly increased in the TPF-treated mice compared to the control mice.

CONCLUSION:

Our findings point towards the stimulation of bone formation by TPF, suggested that the TPF could be a potential natural anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Osteogenesis / Flavonoids / Bone Resorption / Plant Extracts / Bone Density / Cell Differentiation / Asteraceae Type of study: Risk factors Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2017 Type: Article Affiliation country: Bangladesh Institution/Affiliation country: Islami University/BD / Rajshahi University/BD / Shahjalal University of Science and Technology/BD

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Full text: Available Index: LILACS (Americas) Main subject: Osteogenesis / Flavonoids / Bone Resorption / Plant Extracts / Bone Density / Cell Differentiation / Asteraceae Type of study: Risk factors Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2017 Type: Article Affiliation country: Bangladesh Institution/Affiliation country: Islami University/BD / Rajshahi University/BD / Shahjalal University of Science and Technology/BD