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Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
Lin, Ruhui; Li, Long; Zhang, Yingzheng; Huang, Sheng; Chen, Shangjie; Shi, Jiao; Zhuo, Peiyuan; Jin, Hao; Li, Zuanfang; Liu, Weilin; Wang, Zhifu; Chen, Lidian; Tao, Jing.
  • Lin, Ruhui; Center for Rehabilitation Technology. CN
  • Li, Long; Center for Rehabilitation Technology. CN
  • Zhang, Yingzheng; Center for Rehabilitation Technology. CN
  • Huang, Sheng; TCM Rehabilitation Research Center of SATCM. CN
  • Chen, Shangjie; Southern Medical University. Baoan People's Hospital. CN
  • Shi, Jiao; Southern Medical University. Baoan People's Hospital. CN
  • Zhuo, Peiyuan; Center for Rehabilitation Technology. CN
  • Jin, Hao; TCM Rehabilitation Research Center of SATCM. CN
  • Li, Zuanfang; National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology. CN
  • Liu, Weilin; Fujian University of Traditional Chinese Medicine. College of Rehabilitation Medicine. Fujian. CN
  • Wang, Zhifu; National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology. CN
  • Chen, Lidian; National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology. CN
  • Tao, Jing; Fujian University of Traditional Chinese Medicine. College of Rehabilitation Medicine. Fujian. CN
Biol. Res ; 51: 21, 2018. graf
Article in English | LILACS | ID: biblio-950905
ABSTRACT

OBJECTIVE:

To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot.

RESULTS:

EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice.

CONCLUSION:

These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Electroacupuncture / Aspartic Acid / Glutamic Acid / Hippocampus / Learning / Memory Type of study: Prognostic study Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Center for Rehabilitation Technology/CN / Fujian University of Traditional Chinese Medicine/CN / National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology/CN / Southern Medical University/CN / TCM Rehabilitation Research Center of SATCM/CN

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Full text: Available Index: LILACS (Americas) Main subject: Electroacupuncture / Aspartic Acid / Glutamic Acid / Hippocampus / Learning / Memory Type of study: Prognostic study Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Center for Rehabilitation Technology/CN / Fujian University of Traditional Chinese Medicine/CN / National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology/CN / Southern Medical University/CN / TCM Rehabilitation Research Center of SATCM/CN