Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
Biol. Res
;
51: 21, 2018. graf
Article
in English
| LILACS
| ID: biblio-950905
ABSTRACT
OBJECTIVE:
To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot.RESULTS:
EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice.CONCLUSION:
These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Electroacupuncture
/
Aspartic Acid
/
Glutamic Acid
/
Hippocampus
/
Learning
/
Memory
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Center for Rehabilitation Technology/CN
/
Fujian University of Traditional Chinese Medicine/CN
/
National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology/CN
/
Southern Medical University/CN
/
TCM Rehabilitation Research Center of SATCM/CN
Similar
MEDLINE
...
LILACS
LIS