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Prognostic effect of high-flux hemodialysis in patients with chronic kidney disease
Li, X; Xu, H; Xiao, X C; Deng, S L; Wang, W; Tang, R.
Affiliation
  • Li, X; Xiangya Hospital of Central South University. The Hemodialysis Room. Changsha. CN
  • Xu, H; Xiangya Hospital of Central South University. The Hemodialysis Room. Changsha. CN
  • Xiao, X C; Xiangya Hospital of Central South University. The Hemodialysis Room. Changsha. CN
  • Deng, S L; Xiangya Hospital of Central South University. Department of Educational Administration. Changsha. CN
  • Wang, W; Xiangya Hospital of Central South University. The Hemodialysis Room. Changsha. CN
  • Tang, R; Xiangya Hospital of Central South University. The Hemodialysis Room. Changsha. CN
Braz. j. med. biol. res ; 49(1): e4708, 2016. tab, graf
Article in En | LILACS | ID: biblio-951642
Responsible library: BR1.1
ABSTRACT
We investigated the prognostic effects of high-flux hemodialysis (HFHD) and low-flux hemodialysis (LFHD) in patients with chronic kidney disease (CKD). Both an electronic and a manual search were performed based on our rigorous inclusion and exclusion criteria to retrieve high-quality, relevant clinical studies from various scientific literature databases. Comprehensive meta-analysis 2.0 (CMA 2.0) was used for the quantitative analysis. We initially retrieved 227 studies from the database search. Following a multi-step screening process, eight high-quality studies were selected for our meta-analysis. These eight studies included 4967 patients with CKD (2416 patients in the HFHD group, 2551 patients in the LFHD group). The results of our meta-analysis showed that the all-cause death rate in the HFHD group was significantly lower than that in the LFHD group (OR=0.704, 95%CI=0.533-0.929, P=0.013). Additionally, the cardiovascular death rate in the HFHD group was significantly lower than that in the LFHD group (OR=0.731, 95%CI=0.616-0.866, P<0.001). The results of this meta-analysis clearly showed that HFHD decreases all-cause death and cardiovascular death rates in patients with CKD and that HFHD can therefore be implemented as one of the first therapy choices for CKD.
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Full text: 1 Index: LILACS Main subject: Renal Dialysis / Kidney Failure, Chronic Type of study: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2016 Type: Article

Full text: 1 Index: LILACS Main subject: Renal Dialysis / Kidney Failure, Chronic Type of study: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2016 Type: Article