Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells
Braz. j. med. biol. res
;
50(7): e6390, 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-951701
ABSTRACT
Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30) were used in the screening tests.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schiff Bases
/
Skin Neoplasms
/
Cobalt
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2017
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Chongqing Hospital of Traditional Chinese Medicine/CN
/
Southern Medical University/CN
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