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Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
Chen, Jie; Wu, Yu; Yu, Jiannong; Shen, Jinming.
  • Chen, Jie; Zhejiang Provincial Hospital of Traditional Chinese Medicine. Department of Orthopaedics. Hangzhou. CN
  • Wu, Yu; Zhejiang Provincial Hospital of Traditional Chinese Medicine. Department of Orthopaedics. Hangzhou. CN
  • Yu, Jiannong; Zhejiang Provincial Hospital of Traditional Chinese Medicine. Department of Orthopaedics. Hangzhou. CN
  • Shen, Jinming; Zhejiang Provincial Hospital of Traditional Chinese Medicine. Department of Orthopaedics. Hangzhou. CN
Braz. j. med. biol. res ; 51(8): e7311, 2018. tab, graf
Article in English | LILACS | ID: biblio-951745
ABSTRACT
Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.
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Full text: Available Index: LILACS (Americas) Main subject: Tumor Necrosis Factor-alpha / Osteoarthritis, Knee / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Zhejiang Provincial Hospital of Traditional Chinese Medicine/CN

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Full text: Available Index: LILACS (Americas) Main subject: Tumor Necrosis Factor-alpha / Osteoarthritis, Knee / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Zhejiang Provincial Hospital of Traditional Chinese Medicine/CN