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Strontium ranelate inhibits wear particle-induced aseptic loosening in mice
Geng, Tianxiang; Department of Orthopedic SurgerySun, Shouxuan; Yu, Haochen; Department of Orthopedic SurgeryGuo, Haohui; Zheng, Mengxue; Department of Orthopedic SurgeryZhang, Shuai; Chen, Xi; Department of Orthopedic SurgeryJin, Qunhua.
Affiliation
  • Geng, Tianxiang; General Hospital of Ningxia Medical University. Ningxia Medical University. Yinchuan. CN
  • Department of Orthopedic SurgerySun, Shouxuan; Ningxia Medical University. General Hospital of Ningxia Medical University. Department of Orthopedic SurgerySun, Shouxuan. Yinchuan. CN
  • Yu, Haochen; General Hospital of Ningxia Medical University. Ningxia Medical University. Yinchuan. CN
  • Department of Orthopedic SurgeryGuo, Haohui; Ningxia Medical University. General Hospital of Ningxia Medical University. Department of Orthopedic SurgeryGuo, Haohui. Yinchuan. CN
  • Zheng, Mengxue; General Hospital of Ningxia Medical University. Ningxia Medical University. Yinchuan. CN
  • Department of Orthopedic SurgeryZhang, Shuai; Ningxia Medical University. General Hospital of Ningxia Medical University. Department of Orthopedic SurgeryZhang, Shuai. Yinchuan. CN
  • Chen, Xi; General Hospital of Ningxia Medical University. Ningxia Medical University. Yinchuan. CN
  • Department of Orthopedic SurgeryJin, Qunhua; Ningxia Medical University. General Hospital of Ningxia Medical University. Department of Orthopedic SurgeryJin, Qunhua. Yinchuan. CN
Braz. j. med. biol. res ; 51(9): e7414, 2018. graf
Article in En | LILACS | ID: biblio-951755
Responsible library: BR1.1
ABSTRACT
The imbalance between bone formation and osteolysis plays a key role in the pathogenesis of aseptic loosening. Strontium ranelate (SR) can promote bone formation and inhibit osteolysis. The aim of this study was to explore the role and mechanism of SR in aseptic loosening induced by wear particles. Twenty wild-type (WT) female C57BL/6j mice and 20 sclerostin-/- female C57BL/6j mice were used in this study. Mice were randomly divided into four groups WT control group, WT SR group, knockout (KO) control group, and KO SR group. We found that SR enhanced the secretion of osteocalcin (0.72±0.007 in WT control group, 0.98±0.010 in WT SR group, P=0.000), Runx2 (0.34±0.005 in WT control group, 0.47±0.010 in WT SR group, P=0.000), β-catenin (1.04±0.05 in WT control group, 1.22±0.02 in WT SR group, P=0.000), and osteoprotegerin (OPG) (0.59±0.03 in WT control group, 0.90±0.02 in WT SR group, P=0.000). SR significantly decreased the level of receptor activator for nuclear factor-κB ligand (RANKL) (1.78±0.08 in WT control group, 1.37±0.06 in WT SR group, P=0.000) and improved the protein ratio of OPG/RANKL, but these effects were not observed in sclerostin-/- mice. Our findings demonstrated that SR enhanced bone formation and inhibited bone resorption in a wear particle-mediated osteolysis model in wild-type mice, and this effect relied mainly on the down-regulation of sclerostin levels to ameliorate the inhibition of the canonical Wnt pathway.
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Full text: 1 Index: LILACS Main subject: Osteolysis / Artificial Limbs / Thiophenes / Bone Resorption / Prosthesis Implantation / Lower Extremity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2018 Type: Article

Full text: 1 Index: LILACS Main subject: Osteolysis / Artificial Limbs / Thiophenes / Bone Resorption / Prosthesis Implantation / Lower Extremity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2018 Type: Article