Effect of metformin on semen quality
Braz. j. pharm. sci
;
52(4): 591-594, Oct.-Dec. 2016.
Article
in English
| LILACS
| ID: biblio-951874
ABSTRACT
ABSTRACT Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE electronic database for English articles and abstracts containing the key words 'metformin' and 'sperm', and relevant articles were reviewed. In summary, metformin appears to have improved and provided positive impact on sperm quality. This effect may be due to the ability of metformin to reduce oxidative stress and lipid peroxidation, enhance 5'-AMP activated protein kinase activity, and restore the normal levels of pituitary-gonadal hormones. However, further clinical research is still necessary to confirm such effect.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Semen
/
Metformin
Language:
English
Journal:
Braz. j. pharm. sci
Year:
2016
Type:
Article
Affiliation country:
Jordan
Institution/Affiliation country:
Jordan University of Science and Technology/JO
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