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Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery
Chassot, Janaíne Micheli; Ferreira, Luana Mota; Gomes, Felipe Pereira; Silva, Cristiane de Bona da; Tasso, Leandro; Cruz, Letícia.
  • Chassot, Janaíne Micheli; Federal University of Santa Maria. Department of Industrial Pharmacy. Santa Maria. BR
  • Ferreira, Luana Mota; Federal University of Santa Maria. Department of Industrial Pharmacy. Santa Maria. BR
  • Gomes, Felipe Pereira; Federal University of Santa Maria. Department of Industrial Pharmacy. Santa Maria. BR
  • Silva, Cristiane de Bona da; Federal University of Santa Maria. Department of Industrial Pharmacy. Santa Maria. BR
  • Tasso, Leandro; University of Caxias do Sul. Institute of Biotechnology. Caxias do Sul. BR
  • Cruz, Letícia; Federal University of Santa Maria. Department of Industrial Pharmacy. Santa Maria. BR
Braz. j. pharm. sci ; 52(4): 735-740, Oct.-Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-951887
Responsible library: BR40.1
Localization: BR40.1
ABSTRACT
ABSTRACT Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition method of preformed polymers and they were characterized in terms of pH, average diameter, polydispersity index, zeta potential, beclomethasone dipropionate content, encapsulation efficiency, photostability and drug release profiles. The formulations showed physicochemical characteristics consistent with nanocarriers for drug delivery such as average diameter lower than 270 nm, polydispersity indexes lower than 0.2, negative zeta potential (-22.7 to -26.3 mV) and encapsulation efficiencies close to 100%. In addition, the nanocapsules were able to delay the beclomethasone dipropionate photodegradation under UVC radiation and by the dialysis bag diffusion technique, the nanocapsules were able to prolong the drug release. Thus, pullulan could be considered an interesting excipient to formulate polymeric nanocapsules.
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Full text: Available Index: LILACS (Americas) Main subject: Polysaccharides / Biological Products / Excipients / Nanocapsules Language: English Journal: Braz. j. pharm. sci Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Santa Maria/BR / University of Caxias do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Polysaccharides / Biological Products / Excipients / Nanocapsules Language: English Journal: Braz. j. pharm. sci Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Santa Maria/BR / University of Caxias do Sul/BR