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Antihypoxic activities of Crataegus pentaegyn and Crataegus microphylla fruits-an in vivo assay
Ebrahimzadeh, Mohammad Ali; Khalili, Masoumeh; Jafari, Negar; Zareh, Giti; Farzin, Davood; Amin, Gholamreza.
  • Ebrahimzadeh, Mohammad Ali; Mazandaran University of Medical Sciences. School of Pharmacy. Pharmaceutical Sciences Research Center. Sari. IR
  • Khalili, Masoumeh; Golestan University of Medical Sciences. Neuroscience Research Center. Gorgan. IR
  • Jafari, Negar; Mazandaran University of Medical Sciences. School of Pharmacy. Pharmaceutical Sciences Research Center. Sari. IR
  • Zareh, Giti; Mazandaran University of Medical Sciences. School of Pharmacy. Pharmaceutical Sciences Research Center. Sari. IR
  • Farzin, Davood; Mazandaran University of Medical Sciences. School of Medicine. Department of Pharmacology. Sari. IR
  • Amin, Gholamreza; Tehran University of Medical Sciences. Faculty of Pharmacy. Department of Pharmacognosy. Tehran. IR
Braz. J. Pharm. Sci. (Online) ; 54(2): e17363, 2018. tab
Article in English | LILACS | ID: biblio-951923
ABSTRACT
ABSTRACT The aim of this study was to evaluate anti-hypoxia activity of polyphenolic extracts of Crataegus microphylla and Crataegus pentaegyn on mice. Three experimental models of hypoxia were considered, including asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia. Polyphenolic extract of both plants exhibited significant anti-hypoxic activity and prolonged animal survival time. Anti-hypoia activity of C. pentaegyn was found to be superior to that of C. microphylla in circulatory and asphyctic hypoxia. Antihypoxic activity of these extracts may be attributed to their phenolic compounds.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Crataegus / Hypoxia Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Iran Institution/Affiliation country: Golestan University of Medical Sciences/IR / Mazandaran University of Medical Sciences/IR / Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Crataegus / Hypoxia Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Iran Institution/Affiliation country: Golestan University of Medical Sciences/IR / Mazandaran University of Medical Sciences/IR / Tehran University of Medical Sciences/IR