A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
Braz. J. Pharm. Sci. (Online)
;
54(2): e17183, 2018. tab, graf, ilus
Article
in English
| LILACS
| ID: biblio-951934
ABSTRACT
ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Drug Liberation
/
Hydrogen-Ion Concentration
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2018
Type:
Article
/
Project document
Affiliation country:
Colombia
Institution/Affiliation country:
Universidad Nacional de Colombia/CO
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