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Influence of the clinical profile of patients with refractory epilepsy on lamotrigine plasma concentration
Baldoni, André Oliveira; Freitas-Lima, Priscila; Alexandre, Veriano; Ferreira, Flávia Isaura de Santi; Martinez, Edson Zangiacomi; Queiroz, Regina Helena Costa; Sakamoto, Americo Ceiki; Pereira, Leonardo Regis Leira.
  • Baldoni, André Oliveira; Federal University of São João Del-Rei. BR
  • Freitas-Lima, Priscila; University of São Paulo. Ribeirão Preto School of Medicine. BR
  • Alexandre, Veriano; University of São Paulo. Ribeirão Preto School of Medicine. BR
  • Ferreira, Flávia Isaura de Santi; University of São Paulo. Faculty of Pharmaceutical Sciences of Ribeirão Preto. BR
  • Martinez, Edson Zangiacomi; University of São Paulo. Ribeirão Preto School of Medicine. BR
  • Queiroz, Regina Helena Costa; University of São Paulo. Faculty of Pharmaceutical Sciences of Ribeirão Preto. BR
  • Sakamoto, Americo Ceiki; University of São Paulo. Ribeirão Preto School of Medicine. BR
  • Pereira, Leonardo Regis Leira; University of São Paulo. Faculty of Pharmaceutical Sciences of Ribeirão Preto. BR
Braz. J. Pharm. Sci. (Online) ; 54(2): e00246, 2018. tab, graf
Article in English | LILACS | ID: biblio-951938
ABSTRACT
ABSTRACT The purpose of this work was to evaluate the influence of the clinical profile on lamotrigine (LTG) plasma concentrations from patients with refractory epileptic seizures. In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic seizures of a Hospital in Ribeirão Preto-SP-Brazil were performed. The multiple linear regression model was used to verify association between the LTG plasma concentrations and the independent variables. Covariance analysis was used to compare the mean LTG plasma concentration among the co-medication groups. The LTG plasma concentration was associated both with the LTG dosage (mg/kg/day) (p=0.0096) and with the use of first generation antiepileptic drugs (AED) (p<0.01), being carbamazepine (CBZ) and phenytoin (PHT), the AEDs showing the most prominent influence in reducing LTG plasma concentrations. Adverse events, adherence to the pharmacological treatment, and epileptic seizures frequency, did not show significant correlation with LTG plasma concentration values. The conclusion is that LTG plasma concentration is significantly influenced by the LTG dosage and by the concomitant use of a first generation AED.
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Full text: Available Index: LILACS (Americas) Main subject: Drug Interactions / Anticonvulsants Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of São João Del-Rei/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Drug Interactions / Anticonvulsants Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of São João Del-Rei/BR / University of São Paulo/BR