Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model
Braz. J. Pharm. Sci. (Online)
; 54(2): e17171, 2018. tab, graf
Article
in En
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| ID: biblio-951943
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BR1.1
Localization: BR40.1
ABSTRACT
ABSTRACT Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZ-NA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group
Key words
Full text:
1
Index:
LILACS
Main subject:
Streptozocin
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Niacinamide
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Diabetes Mellitus, Experimental
Limits:
Animals
Language:
En
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
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Teraputica
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Toxicologia
Year:
2018
Type:
Article
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Project document