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Analysis of Interleukin 17A in periapical abscess and granuloma lesions
Ferreira, Luciana Gonçalves Valente; Rosin, Flávia Cristina Perillo; Corrêa, Luciana.
  • Ferreira, Luciana Gonçalves Valente; Universidade de São Paulo. School of Dentistry. Department Stomatology. São Paulo. BR
  • Rosin, Flávia Cristina Perillo; Universidade de São Paulo. School of Dentistry. Department Stomatology. São Paulo. BR
  • Corrêa, Luciana; Universidade de São Paulo. School of Dentistry. Department Stomatology. São Paulo. BR
Braz. oral res. (Online) ; 30(1): e34, 2016. graf
Article in English | LILACS | ID: biblio-951990
ABSTRACT
Abstract Interleukin 17A (IL-17A) is a proinflammatory cytokine responsible for the initiation and propagation of inflammation. One of its actions is the recruitment of neutrophils to the site of infection. The aim of this study was to investigate whether there is association between IL-17A expression and neutrophil infiltration in periapical abscesses and periapical granulomas, as well as to find which type of T lymphocyte effector (CD4+ or CD8+) expresses IL-17A in these lesions. Elastase, CD4, CD8, and IL-17A were analyzed by immunohistochemistry and immunofluorescence, in the biopsies of periapical lesions. Abscess lesions exhibited the highest labeling area for IL-17A (p = 0.011). During double immunofluorescence staining, there were significantly more CD4+/IL-17A+ cells compared to CD8+/IL-17A+ cells, both in the abscesses (p = 0.025) and granulomas (p = 0.011). In conclusion, IL-17A was intensively expressed in periapical abscesses rich in neutrophils. The high percentage of IL-17A in these cases suggests the participation of this cytokine particularly in the acute stages of the inflammatory process of the periapical lesions.
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Full text: Available Index: LILACS (Americas) Main subject: Periapical Abscess / Periapical Granuloma / Interleukin-17 Limits: Humans Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Periapical Abscess / Periapical Granuloma / Interleukin-17 Limits: Humans Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR