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Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats
de Rezende Barbosa, Gabriella Lopes; Pimenta, Luiz André; Almeida, Solange Maria de.
  • de Rezende Barbosa, Gabriella Lopes; Universidade de Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Piracicaba. BR
  • Pimenta, Luiz André; University of North Carolina at Chapel Hill. School of Dentistry. Department of Dental Ecology. Chapel Hill. US
  • Almeida, Solange Maria de; Universidade de Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Piracicaba. BR
Braz. oral res. (Online) ; 30(1): e168, 2016. tab, graf
Article in English | LILACS | ID: biblio-951995
ABSTRACT
Abstract The purpose of this study was to perform a microcomputed tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratrol, whereas the irradiated groups were exposed to 15 Gy of irradiation. The animals were sacrificed 30 days after the irradiation procedure, and their mandibles were removed and scanned in a microcomputed tomography unit. The images were loaded into Mimics software to allow segmentation of the mandibular incisor and assessment of its volume. The results were compared by One-way ANOVA and Tukey's post hoc test, considering a 5% significance level. The irradiated groups showed significantly diminished volumes of the evaluated teeth, as compared with the control group (p < 0.05). The resveratrol group presented higher values than those of the irradiated groups, and volumes similar to those of the control group. High radiation doses significantly affected tooth formation, resulting in alterations in the dental structure, and thus lower volumes. Moreover, resveratrol showed no effective radioprotective impact on dental tissues. Future studies are needed to evaluate different concentrations of this substance, in an endeavor to verify its potential as a radioprotector for these dental tissues.
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Full text: Available Index: LILACS (Americas) Main subject: Radiation Injuries, Experimental / Radiation-Protective Agents / Stilbenes / X-Ray Microtomography / Incisor / Odontogenesis Type of study: Evaluation studies Limits: Animals Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2016 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Universidade de Campinas/BR / University of North Carolina at Chapel Hill/US

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Full text: Available Index: LILACS (Americas) Main subject: Radiation Injuries, Experimental / Radiation-Protective Agents / Stilbenes / X-Ray Microtomography / Incisor / Odontogenesis Type of study: Evaluation studies Limits: Animals Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2016 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Universidade de Campinas/BR / University of North Carolina at Chapel Hill/US