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Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review
Humberto, Janaina Silva Martins; Pavanin, Jefferson Veronezi; Rocha, Maria José Alves da; Motta, Ana Carolina Fragoso.
  • Humberto, Janaina Silva Martins; Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Morphology, Physiology, and Basic Pathology. Ribeirão Preto. BR
  • Pavanin, Jefferson Veronezi; Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Stomatology. Ribeirão Preto. BR
  • Rocha, Maria José Alves da; Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Morphology, Physiology, and Basic Pathology. Ribeirão Preto. BR
  • Motta, Ana Carolina Fragoso; Universidade de São Paulo. School of Dentistry of Ribeirão Preto. Department of Stomatology. Ribeirão Preto. BR
Braz. oral res. (Online) ; 32: e82, 2018. tab, graf
Article in English | LILACS | ID: biblio-952160
ABSTRACT
Abstract The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-ү, and TNF-α, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP.
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Full text: Available Index: LILACS (Americas) Main subject: Saliva / Hydrocortisone / Cytokines / Lichen Planus, Oral / Nitric Oxide Type of study: Practice guideline / Observational study / Prognostic study / Systematic reviews Limits: Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Saliva / Hydrocortisone / Cytokines / Lichen Planus, Oral / Nitric Oxide Type of study: Practice guideline / Observational study / Prognostic study / Systematic reviews Limits: Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR