Relationships between female infertility and female genital infections and pelvic inflammatory disease: a population-based nested controlled study
Clinics
;
73: e364, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-952793
ABSTRACT
OBJECTIVES:
Our purpose was to examine the associations of female genital infections and certain comorbidities with infertility.METHODS:
The Taiwan National Health Research Database was searched for women with a new diagnosis of infertility between 2000 and 2013. Women without a diagnosis of infertility served as a control group and were matched with the infertility cases by age (±3 years) and index year. They were divided into two groups ≤40 years old and >40 years old. Univariate and multivariate conditional logistic regression models were employed to identify the risk factors associated with infertility.RESULTS:
A total of 18,276 women with a new diagnosis of infertility and 73,104 matched controls (mean cohort age, 31±6.2 years) were included. According to the adjusted multivariate analysis, pelvic inflammatory disease involving the ovary, fallopian tube, pelvic cellular tissue, peritoneum (odds ratio (OR)=4.823), and uterus (OR=3.050) and cervical, vaginal, and vulvar inflammation (OR=7.788) were associated with an increased risk of infertility in women aged ≤40 years. In women aged >40 years, pelvic inflammatory disease of the ovary, fallopian tube, pelvic cellular tissue, and peritoneum (OR=6.028) and cervical, vaginal, and vulvar inflammation (OR=6.648) were associated with infertility. Obesity, lipid metabolism disorders, dysthyroidism, abortion (spontaneous or induced), bacterial vaginosis, endometritis, and tubo-ovarian abscess were associated with an increased risk of infertility according to the univariate analysis but not the multivariate analysis.CONCLUSIONS:
Female genital tract infections, but not the comorbidities studied here, are associated with an increased risk of infertility.
Full text:
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Index:
LILACS (Americas)
Main subject:
Pelvic Inflammatory Disease
/
Reproductive Tract Infections
/
Infertility, Female
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
China
/
Taiwan
Institution/Affiliation country:
Min-Sheng General Hospital/TW
/
Sun Yat-sen University/CN
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