Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
Clinics
;
73: e256, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-952810
ABSTRACT
OBJECTIVES:
The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test.METHODS:
This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFα) and C-reactive protein.RESULTS:
Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 - 4.60, p=0.049) for TNFα, 2.23 (1.06 - 6.54, p=0.037) for IL-6, 2.66 (1.06 - 6.70, p=0.037) for IL-8 and 2.08 (1.01 - 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04).CONCLUSIONS:
C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ventilator Weaning
/
Inflammation
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro Universitario - IPA/BR
/
Centro Universitario Ritter dos Reis/BR
/
Faculdade Cenecista/BR
/
Hospital Moinhos de Vento/BR
/
Hospital de Clinicas de Porto Alegre/BR
/
Universidade Federal do Rio Grande do Sul/BR
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