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Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management
da Cunha Colombo Bonadio, Renata Rodrigues; Fogace, Rodrigo Nogueira; Miranda, Vanessa Costa; Diz, Maria del Pilar Estevez.
  • da Cunha Colombo Bonadio, Renata Rodrigues; Universidade de Sao Paulo. Hospital das Clinicas. Instituto do Cancer do Estado de Sao Paulo (ICESP). Sao Paulo. BR
  • Fogace, Rodrigo Nogueira; Universidade de Sao Paulo. Hospital das Clinicas. Instituto do Cancer do Estado de Sao Paulo (ICESP). Sao Paulo. BR
  • Miranda, Vanessa Costa; Universidade de Sao Paulo. Hospital das Clinicas. Instituto do Cancer do Estado de Sao Paulo (ICESP). Sao Paulo. BR
  • Diz, Maria del Pilar Estevez; Universidade de Sao Paulo. Hospital das Clinicas. Instituto do Cancer do Estado de Sao Paulo (ICESP). Sao Paulo. BR
Clinics ; 73(supl.1): e450s, 2018. tab
Article in English | LILACS | ID: biblio-952825
ABSTRACT
Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed. Germline mutations in the BRCA 1/2 genes are the most well-known mechanisms of homologous recombination deficiency. However, other mechanisms, such as germline and somatic mutations in other homologous recombination genes and epigenetic modifications, have also been implicated in homologous recombination deficiency. The epidemiology and implications of these other mechanisms need to be better understood to improve the treatment strategies for these patients. Furthermore, an evaluation of various diagnostic tests to investigate homologous recombination deficiency is essential. Comprehension of the role of homologous recombination deficiency in ovarian cancer also allows the development of therapeutic combinations that can improve the efficacy of treatment. In this review, we discuss the epidemiology and management of homologous recombination deficiency in ovarian cancer patients.
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Full text: Available Index: LILACS (Americas) Main subject: Ovarian Neoplasms / Germ-Line Mutation / Homologous Recombination / Carcinoma, Ovarian Epithelial Type of study: Screening study Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Ovarian Neoplasms / Germ-Line Mutation / Homologous Recombination / Carcinoma, Ovarian Epithelial Type of study: Screening study Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR