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Lessons and perspectives for applications of stochastic models in biological and cancer research
Sabino, Alan U; Vasconcelos, Miguel FS; Sittoni, Misaki Yamada; Lautenschlager, Willian W; Queiroga, Alexandre S; Morais, Mauro CC; Ramos, Alexandre F.
  • Sabino, Alan U; Universidade de Sao Paulo. Escola de Artes Ciências e Humanidades (EACH). Sao Paulo. BR
  • Vasconcelos, Miguel FS; Universidade de Sao Paulo. Escola de Artes Ciências e Humanidades (EACH). Sao Paulo. BR
  • Sittoni, Misaki Yamada; Universidade de Sao Paulo. Escola de Artes Ciências e Humanidades (EACH). Sao Paulo. BR
  • Lautenschlager, Willian W; Universidade de Sao Paulo. Escola de Artes Ciências e Humanidades (EACH). Sao Paulo. BR
  • Queiroga, Alexandre S; Universidade de Sao Paulo. Escola de Artes Ciências e Humanidades (EACH). Sao Paulo. BR
  • Morais, Mauro CC; Universidade de Sao Paulo. Escola de Artes Ciências e Humanidades (EACH). Sao Paulo. BR
  • Ramos, Alexandre F; Universidade de Sao Paulo. Escola de Artes Ciências e Humanidades (EACH). Sao Paulo. BR
Clinics ; 73(supl.1): e536s, 2018. tab, graf
Article in English | LILACS | ID: biblio-952833
ABSTRACT
The effects of randomness, an unavoidable feature of intracellular environments, are observed at higher hierarchical levels of living matter organization, such as cells, tissues, and organisms. Additionally, the many compounds interacting as a well-orchestrated network of reactions increase the difficulties of assessing these systems using only experiments. This limitation indicates that elucidation of the dynamics of biological systems is a complex task that will benefit from the establishment of principles to help describe, categorize, and predict the behavior of these systems. The theoretical machinery already available, or ones to be discovered to help solve biological problems, might play an important role in these processes. Here, we demonstrate the application of theoretical tools by discussing some biological problems that we have approached mathematically fluctuations in gene expression and cell proliferation in the context of loss of contact inhibition. We discuss the methods that have been employed to provide the reader with a biologically motivated phenomenological perspective of the use of theoretical methods. Finally, we end this review with a discussion of new research perspectives motivated by our results.
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Full text: Available Index: LILACS (Americas) Main subject: Gene Expression Regulation, Neoplastic / Stochastic Processes / Models, Biological / Neoplasms Type of study: Prognostic study / Qualitative research Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Gene Expression Regulation, Neoplastic / Stochastic Processes / Models, Biological / Neoplasms Type of study: Prognostic study / Qualitative research Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR