Marine drugs for cancer: surfacing biotechnological innovations from the oceans
Clinics
;
73(supl.1): e482s, 2018. graf
Article
in English
| LILACS
| ID: biblio-952842
ABSTRACT
This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of these drugs has afforded valuable knowledge and crucial insights to meet the most common challenges in this endeavor, such as toxicity and supply. In this context, the development of these compounds will be discussed herein to illustrate, with successful examples provided by cytarabine, trabectedin, eribulin and brentuximab vedotin, the steps involved in this process as well as the scientific advances and technological innovation potential associated with developing a new drug from marine resources.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biotechnology
/
Aquatic Organisms
/
Drug Development
/
Neoplasms
/
Antineoplastic Agents
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Sao Paulo/BR
/
Universidade Federal do Ceara/BR
/
Universidade de Sao Paulo/BR
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