The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury
Int. braz. j. urol
;
44(3): 617-622, May-June 2018. graf
Article
in English
| LILACS
| ID: biblio-954058
ABSTRACT
ABSTRACT Objective:
To investigate the effect of papaverine and alprostadil on testicular torsion-detorsion injury in rats. Materials andMethods:
A total of 40 male Wistar-Albino rats were used in this study. Four hours of right testicular torsion was applied to each group, excluding sham oper- ated group. The torsion-detorsion (T/D), T/D + papaverine and T/D + alprostadil groups received saline, papaverine and alprostadil at the same time as surgical detorsion, respectively. At 14 days after the surgical detorsion, ischaemic changes and the degree of damage were evaluated with Cosentino scoring and the Johnson tubular biopsy score (JTBS).Results:
JTBS was determined as 8.8±2.7 in the Sham group, 5.08±1.9 in the T/D+papaverine group, 5.29±2.3 in the T/D +alprostadil group and 2.86±1.9 in the TD group. The JTBS was determined to be statistically significantly high in both the T/D + papaverine group and the T/D + alprostadil group compared to the T/D group (p=0.01, p=0.009). In the T/D + papaverine group, 3 (43%) testes were classified as Cosentino 2, 3 (43%) as Cosentino 3 and 1 (14%) as Cosentino 4. In the T/D +alprostadil group, 5 (50 %) testes were classified as Cosentino 2, 3 (30 %) as Cosentino 3 and 2 (20%) as Cosentino 4.Conclusion:
The present study indicated that spermatic cord administration of alprostadil and papaverine showed a protective effect against ischemia/reperfusion injury after right-side testes torsion and histological changes were decreased after testicular ischemia reperfusion injury.
Full text:
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Index:
LILACS (Americas)
Main subject:
Papaverine
/
Spermatic Cord Torsion
/
Testis
/
Vasodilator Agents
/
Alprostadil
/
Ischemia
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2018
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Ankara Training and Research Hospital/TR
/
Canakkale Onsekiz Mart University/TR
/
Necmettin Erbakan University Meram/TR
/
Saglik Bakanligi Ankara Egitim ve Arastirma/TR
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