Your browser doesn't support javascript.
loading
The diagnostic value of FNDC5/irisin in renal cell cancer
Altay, Diler Us; Keha, Esref Edip; Karagüzel, Ersagun; Mentese, Ahmet; Yaman, Serap Ozer; Alver, Ahmet.
  • Altay, Diler Us; Ordu University. Laboratory Technology Program. Ulubey Vocational School. Ordu. TR
  • Keha, Esref Edip; Karadeniz Technical University. Faculty of Medicine. Department of Medical Biochemistry. Trabzon. TR
  • Karagüzel, Ersagun; Karadeniz Technical University. Faculty of Medicine. Department of Urology. Trabzon. TR
  • Mentese, Ahmet; Karadeniz Technical University. Faculty of Medicine. Department of Medical Biochemistry. Trabzon. TR
  • Yaman, Serap Ozer; Karadeniz Technical University. Faculty of Medicine. Department of Medical Biochemistry. Trabzon. TR
  • Alver, Ahmet; Karadeniz Technical University. Faculty of Medicine. Department of Medical Biochemistry. Trabzon. TR
Int. braz. j. urol ; 44(4): 734-739, July-Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-954089
ABSTRACT
ABSTRACT

Purposes:

The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and

Methods:

In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA).

Results:

FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were >105pg/mL and CEA were >2.67ng/mL for renal cancer.

Conclusions:

FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Renal Cell / Carcinoembryonic Antigen / Fibronectins / Kidney Neoplasms Type of study: Diagnostic study / Evaluation studies / Observational study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Karadeniz Technical University/TR / Ordu University/TR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Renal Cell / Carcinoembryonic Antigen / Fibronectins / Kidney Neoplasms Type of study: Diagnostic study / Evaluation studies / Observational study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Karadeniz Technical University/TR / Ordu University/TR