Risk factors for human Mycobacterium bovis infections in an urban area of Brazil
Mem. Inst. Oswaldo Cruz
;
113(8): e170445, 2018. tab
Article
in English
| LILACS
| ID: biblio-955115
ABSTRACT
BACKGROUND The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study. OBJECTIVE The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes. METHODS A matched case-control study was carried out nested within a cross-sectional study. For each of the three cases, 14 age- and sex-matched controls (TB due to M. tuberculosis) were selected. FINDINGS Zoonotic potential exposures (ZE) and extrapulmonary TB (EPTB) were independently associated with zoonotic TB in multivariate analyses. CONCLUSIONS ZE by occupation and consumption of raw milk and derivative products that place individuals in direct and indirect contact with animals and their excretions/secretions increase the risk for zoonotic TB in Brazil, especially among those with EPTB. Therefore, measures such as efficient control of bovine TB, distribution of pasteurised milk and its derivative products, and the diagnosis and monitoring of zoonotic TB in humans are essential steps, especially in developing countries where bovine TB is enzootic, and further studies are necessary.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tuberculosis
/
Tuberculosis, Bovine
/
Mycobacterium bovis
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Animals
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2018
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Embrapa Gado de Corte/BR
/
Embrapa Gado de Leite/BR
/
Fundação Oswaldo Cruz-Fiocruz/BR
/
Hospital Regional João Penido/BR
/
Ministério da Agricultura, Pecuária e Abastecimento/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal de Viçosa/BR
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