Gluten and Neuroimmunology. Rare association with Myasthenia Gravis and Literature Review
Rev. Assoc. Med. Bras. (1992)
;
64(4): 311-314, Apr. 2018. graf
Article
in English
| LILACS
| ID: biblio-956451
ABSTRACT
SUMMARY As the celiac disease (CD), the non-celiac gluten sensitivity (NCGS) has also been associated with several autoimmune manifestations. It is rarely associated with myasthenia gravis (MG). This paper shall introduce the case of a young female patient, initially presenting a peripheral neuropathy framework. During clinical and neurological follow-up, she began to present symptoms of various immune-mediated morbidities. Diseases related to gluten represent a clinical spectrum of manifestations with a trigger in common, the ingestion of gluten. CD is the most well-known and serious disease of the spectrum, also called gluten-sensitive enteropathy. The NCGS is diagnosed from clinical evidence of improvement in symptoms followed by a Gluten Free Diet (GFD) in patients without signs of enteropathy in duodenal biopsy. There are indications that, although rare, with a prevalence of 1 in 5000, myasthenia gravis (MG) may occur more often when CD is also present. Between 13 to 22% of the patients with MG have a second autoimmune disorder. However, it is often associated with dermatomyositis or polymyositis, lupus erythematosussystemic lupus erythematosus, Addison's disease, Guillain-Barré syndrome and juvenile rheumatoid arthritis. Thus, the symptoms of neuromuscular junction involvement may give a diagnostic evidence of this rare association.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ataxia
/
Food Hypersensitivity
/
Glutens
/
Myasthenia Gravis
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Santa Casa/BR
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