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Mucosal leishmaniasis: the experience of a Brazilian referral center
Pedras, Mariana Junqueira; Carvalho, Janaína de Pina; Silva, Rosiana Estéfane da; Ramalho, Dario Brock; Senna, Maria Camilo Ribeiro de; Moreira, Hugo Silva Assis; Martinho, Lorena Zaine Matos; Rabello, Ana; Cota, Gláucia.
  • Pedras, Mariana Junqueira; Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Carvalho, Janaína de Pina; Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Silva, Rosiana Estéfane da; Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Ramalho, Dario Brock; Fundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte. BR
  • Senna, Maria Camilo Ribeiro de; Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Moreira, Hugo Silva Assis; Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Martinho, Lorena Zaine Matos; Fundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte. BR
  • Rabello, Ana; Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Cota, Gláucia; Fundação Oswaldo Cruz. Instituto René Rachou. Pesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
Rev. Soc. Bras. Med. Trop ; 51(3): 318-323, Apr.-June 2018. tab, graf
Article in English | LILACS | ID: biblio-957424
Responsible library: BR1.1
ABSTRACT
Abstract INTRODUCTION Pentavalent antimonials (Sbv) are the most commonly used drugs for the treatment of mucosal leishmaniasis (ML), despite their high toxicity and only moderate efficacy. The aim of this study was to report therapeutic responses with different available options for ML. METHODS This study was based on a review of clinical records of 35 patients (24 men and 11 women) treated between 2009 and 2015. RESULTS The median age of patients was 63 years, and the median duration of the disease was 24 months. Seventeen patients received Sbv, while nine patients were treated with liposomal amphotericin B (AmB), and another nine patients were treated with fluconazole. Patients treated with AmB received a total median accumulated dose of 2550mg. The mean duration of azole use was 120 days, and the daily dose ranged from 450 to 900mg. At the three-month follow-up visit, the cure rate was 35%, 67%, and 22% for Sbv, AmB, and azole groups, respectively. At the six-month follow-up visit, the cure rates for Sbv, AmB, and azole groups were 71%, 78%, and 33%, respectively. CONCLUSIONS There is a scarcity of effective ML treatment alternatives, and based on our observations, fluconazole is not a valid treatment option.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Leishmaniasis, Mucocutaneous / Fluconazole / Amphotericin B / Antimony / Antiprotozoal Agents Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Hospitalar do Estado de Minas Gerais/BR / Fundação Oswaldo Cruz/BR

Full text: Available Index: LILACS (Americas) Main subject: Leishmaniasis, Mucocutaneous / Fluconazole / Amphotericin B / Antimony / Antiprotozoal Agents Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Hospitalar do Estado de Minas Gerais/BR / Fundação Oswaldo Cruz/BR