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Hepatitis B and asymptomatic malaria coinfection in Sub-Saharan African immigrants: epidemiological and clinical features of HBV infection
Scotto, Gaetano; Fazio, Vincenzina.
  • Scotto, Gaetano; University of Foggia. Faculty of Medicine and Surgery. Microbiology and Clinical Microbiology. Foggia. IT
  • Fazio, Vincenzina; Public Health and Preventive Medicine. Clinical Laboratory specialist. Foggia. IT
Rev. Soc. Bras. Med. Trop ; 51(5): 578-583, Sept.-Oct. 2018. tab
Article in English | LILACS | ID: biblio-957468
ABSTRACT
Abstract

INTRODUCTION:

Here, we conducted an epidemiological study of hepatitis B virus (HBV) mono-infected and asymptomatic malaria/HBV coinfected immigrants and further discussed the possibility of malaria disease modifying the clinical presentation of HBV infection.

METHODS:

A total of 195 African immigrants were examined for HBV infection or coinfection with HBV and asymptomatic malaria. HBV infection was diagnosed using serological tests and confirmed by PCR; furthermore, we performed a pan-Plasmodium-specific-nucleic-acid-sequence-based-amplification (NASBA) assay to detect asymptomatic malaria infection. The stage/grade of the liver disease was determined using echotomography and elastometry.

RESULTS:

PCR-NASBA results confirmed that 62 of 195 subjects (31.8%) were positive for Plasmodium infection, whereas 41 of 195 subjects (21%) tested positive for HBV chronic hepatitis (HBV-DNA positive). Among the HBV-positive subjects, 26 (63.4%) of them were mono-infected patients (Group A), whereas 15 (36.6%) patients had HBV chronic hepatitis and asymptomatic malaria coinfections (Group B). The HBV-DNA median levels were 1.4×105IU/mL in HBV-mono-infected patients and 2.0×105IU/mL in coinfected patients. Echotomography and hepatic elastometry presented similar findings for both groups of patients.

CONCLUSIONS:

Coinfected patients seem to present with the same clinical symptoms of the liver disease as HBV mono-infected patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Emigrants and Immigrants / Asymptomatic Infections / Coinfection / Hepatitis B / Malaria Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Africa / Europa Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Italy Institution/Affiliation country: Public Health and Preventive Medicine/IT / University of Foggia/IT

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Full text: Available Index: LILACS (Americas) Main subject: Emigrants and Immigrants / Asymptomatic Infections / Coinfection / Hepatitis B / Malaria Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Africa / Europa Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Italy Institution/Affiliation country: Public Health and Preventive Medicine/IT / University of Foggia/IT