Hepatitis B and asymptomatic malaria coinfection in Sub-Saharan African immigrants: epidemiological and clinical features of HBV infection
Rev. Soc. Bras. Med. Trop
;
51(5): 578-583, Sept.-Oct. 2018. tab
Article
in English
| LILACS
| ID: biblio-957468
ABSTRACT
Abstract INTRODUCTION:
Here, we conducted an epidemiological study of hepatitis B virus (HBV) mono-infected and asymptomatic malaria/HBV coinfected immigrants and further discussed the possibility of malaria disease modifying the clinical presentation of HBV infection.METHODS:
A total of 195 African immigrants were examined for HBV infection or coinfection with HBV and asymptomatic malaria. HBV infection was diagnosed using serological tests and confirmed by PCR; furthermore, we performed a pan-Plasmodium-specific-nucleic-acid-sequence-based-amplification (NASBA) assay to detect asymptomatic malaria infection. The stage/grade of the liver disease was determined using echotomography and elastometry.RESULTS:
PCR-NASBA results confirmed that 62 of 195 subjects (31.8%) were positive for Plasmodium infection, whereas 41 of 195 subjects (21%) tested positive for HBV chronic hepatitis (HBV-DNA positive). Among the HBV-positive subjects, 26 (63.4%) of them were mono-infected patients (Group A), whereas 15 (36.6%) patients had HBV chronic hepatitis and asymptomatic malaria coinfections (Group B). The HBV-DNA median levels were 1.4×105IU/mL in HBV-mono-infected patients and 2.0×105IU/mL in coinfected patients. Echotomography and hepatic elastometry presented similar findings for both groups of patients.CONCLUSIONS:
Coinfected patients seem to present with the same clinical symptoms of the liver disease as HBV mono-infected patients.
Full text:
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Index:
LILACS (Americas)
Main subject:
Emigrants and Immigrants
/
Asymptomatic Infections
/
Coinfection
/
Hepatitis B
/
Malaria
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Africa
/
Europa
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2018
Type:
Article
Affiliation country:
Italy
Institution/Affiliation country:
Public Health and Preventive Medicine/IT
/
University of Foggia/IT
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