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Effect of ischemic postconditioning and atorvastatin in the prevention of remote lung reperfusion injury
Santos, Carlos Henrique Marques dos; Dourado, Doroty Mesquita; Silva, Baldomero Antonio Kato da; Pontes, Henrique Budib Dorsa; Azevedo Neto, Euler de; Vendas, Giovanna Serra da Cruz; Chaves, Ian de Oliveira; Miranda, João Victor Cunha; Oliva, João Victor Durães Gomes; Dias, Letícia do Espírito Santo; Almeida, Murillo Henrique Martins de; Sampaio, Trícia Luna.
  • Santos, Carlos Henrique Marques dos; Universidade Anhanguera. Campo Grande. BR
  • Dourado, Doroty Mesquita; Universidade Anhanguera. Campo Grande. BR
  • Silva, Baldomero Antonio Kato da; Universidade Federal do Piauí. Teresina. BR
  • Pontes, Henrique Budib Dorsa; Universidade Anhanguera. Campo Grande. BR
  • Azevedo Neto, Euler de; Universidade Anhanguera. Campo Grande. BR
  • Vendas, Giovanna Serra da Cruz; Universidade Anhanguera. Campo Grande. BR
  • Chaves, Ian de Oliveira; Universidade Anhanguera. Campo Grande. BR
  • Miranda, João Victor Cunha; Universidade Anhanguera. Campo Grande. BR
  • Oliva, João Victor Durães Gomes; Universidade Anhanguera. Campo Grande. BR
  • Dias, Letícia do Espírito Santo; Universidade Anhanguera. Campo Grande. BR
  • Almeida, Murillo Henrique Martins de; Universidade Anhanguera. Campo Grande. BR
  • Sampaio, Trícia Luna; Universidade Anhanguera. Campo Grande. BR
Rev. bras. cir. cardiovasc ; 33(2): 115-121, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-958394
Responsible library: BR1.1
ABSTRACT
Abstract

Objective:

The aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic clamping.

Methods:

We used 41 Wistar norvegic rats, which were distributed into 5 groups ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + atorvastatin (IPC+A), atorvastatin (A) and SHAM. It was performed a medium laparotomy, dissection and isolation of the infra-renal abdominal aorta; except for the SHAM group, all the others were submitted to the aortic clamping for 70 minutes (ischemia) and posterior clamp removal (reperfusion, 70 minutes). In the IPC and IPC+A groups, postconditioning was performed between the ischemia and reperfusion phases by four cycles of reperfusion and ischemia lasting 30 seconds each. In the IPC+A and A groups, preceding the surgical procedure, administration of 3.4 mg/day of atorvastatin was performed for seven days by gavage. After the surgical procedure, the right caudal lobe was removed from the lung for histological study, using tissue injury score ranging from grade 1 (normal tissue) to grade 4 (intense lesion).

Results:

The mean lung injury was 3.6 in the I/R group, 1.6 in the IPC group, 1.2 in the IPC+A group, 1.2 in the A group, and 1 in the SHAM group (P<0.01).

Conclusion:

Ischemic postconditioning and atorvastatin were able to minimize lung reperfusion injury, alone or in combination.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Ischemic Postconditioning / Atorvastatin / Lung Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Anhanguera/BR / Universidade Federal do Piauí/BR

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Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Ischemic Postconditioning / Atorvastatin / Lung Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Anhanguera/BR / Universidade Federal do Piauí/BR