Protective effects of baicalin on experimental myocardial infarction in rats
Rev. bras. cir. cardiovasc
;
33(4): 384-390, July-Aug. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-958430
ABSTRACT
Abstract Objective:
This study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms.Methods:
Fifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and high-dose baicalin groups. The latter 3 groups were intraperitoneally injected with baicalin, with a dose of 12.5, 25 and 50 mg/kg, respectively. Then, the myocardial infarction model was established. The hemodynamic of rats was tested, the serum lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), prostacyclin (PGI2) and thromboxane A2 (TXA2) were determined, the myocardial superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected, and the myocardial B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X (Bax) protein expressions were determined.Results:
Compared with the model group, in the high-dose baicalin group the ST segment height and LVEDP were significantly decreased (P<0.05), the LVSP was significantly increased (P<0.05), the serum LDH, CK-MB and TXA2 levels were significantly decreased (P<0.05), the PGI2 level was significantly increased (P<0.05), the myocardial SOD level was significantly increased (P<0.05), and the myocardial MDA level was significantly decreased (P<0.05); the myocardial Bcl-2 protein level was significantly increased, and the Bax protein level was significantly decreased (P<0.05).Conclusion:
Baicalin has protective effects on myocardial infarction in rats. The possible mechanisms may be related to its resistance to oxidative stress, and up-regulation of Bcl-2 protein expression and down-regulation of Bax protein expression in myocardial tissue.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Flavonoids
/
Protective Agents
/
Myocardial Infarction
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Rev. bras. cir. cardiovasc
Journal subject:
Cardiology
/
General Surgery
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
General Hospital of Chengdu Military Region/CN
/
Nanchong Central Hospital/CN
/
Nanchong Senior High School/CN
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