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Randomized controlled trial of Panax ginseng in patients with irritable bowel syndrome
Rocha, Heraldo A.C.; Rocha, Thiago V.; Nóbrega, Fernando J.F.; Morais, Liana C.S.; Diniz, Margareth F.F.M..
  • Rocha, Heraldo A.C.; Universidade Federal da Paraíba. Centro de Ciências Médicas. Departamento de Medicina Interna. João Pessoa. BR
  • Rocha, Thiago V.; Faculdade de Medicina Nova Esperança. João Pessoa. BR
  • Nóbrega, Fernando J.F.; Universidade Federal da Paraíba. Hospital Universitário Lauro Wanderley. Unidade do Aparelho Digestivo. João Pessoa. BR
  • Morais, Liana C.S.; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. João Pessoa. BR
  • Diniz, Margareth F.F.M.; Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. João Pessoa. BR
Rev. bras. farmacogn ; 28(2): 218-222, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-958860
ABSTRACT
ABSTRACT The irritable bowel syndrome is defined as the presence of continuing or recurrent abdominal pain and it is associated with altered bowel habit. Experimental studies with Panax ginseng C.A. Mey., Araliaceae, have demonstrated the antinociceptive action on calcium and sodium channels, as well as on primary sensory neurons. A clinical double-blind, randomized, prospective and experimental trial was conducted for sixty days, comparing the action of dry extract of P. ginseng (300 mg/day) with trimebutine (600 mg/day). Patients were assessed at four visits for abdominal pain, using the Likert scale, and adverse events. Twenty-four patients completed the study, being 87.5% female and mean age of 47.41 years. There was improvement in abdominal pain, through Likert scale values, in patients who used P. ginseng. This group started from a median basal of −5 to 2.5, 3 and 5 in the 1st, 4th and 8th weeks of treatment, respectively, with a statistically significant difference. Similar results were achieved in those patients who used trimebutine. The only adverse effect observed was the occurrence of headache in two patients (16.66%) in the group that used the herbal. The research suggests that P. ginseng was effective in the control of abdominal pain in irritable bowel syndrome patients, analogous to trimebutin, and may be used in future studies for a better evaluation of the obtained results.


Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina Nova Esperança/BR / Universidade Federal da Paraíba/BR

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Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina Nova Esperança/BR / Universidade Federal da Paraíba/BR