New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic effect on human tumor cell lines
Rev. bras. farmacogn
;
28(3): 333-338, May-June 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-958864
ABSTRACT
ABSTRACT The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1",2"-epoxy-3"-hydroxy-3"-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2',6'-dimethoxy-4',5'-(2",2"-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and its glucoside, p-cumaric acid and cinnamic acid. The structures of all compounds were established on the basis of spectroscopic methods, mainly 1D and 2D NMR and HRESIMS, involving comparison with literature data. Cytotoxicity of compounds 1-4 was evaluated against AGP-01 (cancerous ascitic fluid), HCT-116 (colon adenocarcinoma), HL-60 (leukemia), PC-3 (prostate carcinoma), SF-295 (glioblastoma) and SKMEL 28 (melanoma) cell lines.
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Embrapa Agroindústria Tropical/BR
/
Instituto Federal de Educação, Ciência e Tecnologia do Ceará/BR
/
Universidade Federal Rural do Rio de Janeiro/BR
/
Universidade Federal do Ceará/BR
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