Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena / Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults
Rev. méd. Chile
;
146(6): 717-726, jun. 2018. tab, graf
Article
in Spanish
| LILACS
| ID: biblio-961452
ABSTRACT
Background:
Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity.Aim:
To investigate the association of FTO gene with adiposity markers in Chilean adults. Material andMethods:
409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio.Results:
A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI) 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score.Conclusions:
This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
Full text:
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Index:
LILACS (Americas)
Main subject:
Adiposity
/
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
/
Genotype
/
Obesity
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
Chile
/
Colombia
/
United kingdom
Institution/Affiliation country:
Universidad Austral de Chile/CL
/
Universidad Católica de la Santísima Concepción/CL
/
Universidad San Sebastián/CL
/
Universidad Santo Tomás/CL
/
Universidad de Chile/CL
/
Universidad de Concepción/CL
/
Universidad del Rosario/CO
/
University of Glasgow/GB
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