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Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena / Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults
Petermann, Fanny; Villagrán, Marcelo; Troncoso, Claudia; Mardones, Lorena; Leiva, Ana María; Martínez, María Adela; Garrido-Méndez, Alex; Poblete-Valderrama, Felipe; Salas-Bravo, Carlos; Ramírez-Vélez, Robinson; Ulloa, Natalia; Pérez-Bravo, Francisco; Celis-Morales, Carlos.
  • Petermann, Fanny; University of Glasgow. Institute of Cardiovascular and Medical Sciences. BHF Glasgow Cardiovascular Research Centre. Glasgow. GB
  • Villagrán, Marcelo; Universidad Católica de la Santísima Concepción. Departamento de Ciencias Básicas. Concepción. CL
  • Troncoso, Claudia; Universidad Católica de la Santísima Concepción. Facultad de Medicina. CIEDE-USCS y Departamento de Ciencias Clínicas y Preclínicas. Concepción. CL
  • Mardones, Lorena; Universidad Católica de la Santísima Concepción. Departamento de Ciencias Básicas. Concepción. CL
  • Leiva, Ana María; Universidad Austral de Chile. Facultad de Medicina. Instituto de Anatomía, Histología y Patología. Valdivia. CL
  • Martínez, María Adela; Universidad Austral de Chile. Facultad de Ciencias. Instituto de Farmacia. Valdivia. CL
  • Garrido-Méndez, Alex; Universidad San Sebastián. Escuela de Educación Física. Concepción. CL
  • Poblete-Valderrama, Felipe; Universidad Santo Tomás. Facultad de Salud. Escuela de Kinesiología. Sede Valdivia. CL
  • Salas-Bravo, Carlos; Universidad de Concepción. Facultad de Educación. Departamento de Educación Física. Concepción. CL
  • Ramírez-Vélez, Robinson; Universidad del Rosario. Centro de Estudios en Medición de la Actividad Física (CEMA). Bogotá. CO
  • Ulloa, Natalia; Universidad de Concepción. Facultad de Farmacia y Centro de Vida Saludable. Departamento de Bioquímica Clínica e Inmunología. Concepción. CL
  • Pérez-Bravo, Francisco; Universidad de Chile. Escuela de Medicina. Departamento de Nutrición. Santiago. CL
  • Celis-Morales, Carlos; University of Glasgow. Institute of Cardiovascular and Medical Sciences. BHF Glasgow Cardiovascular Research Centre. Glasgow. GB
Rev. méd. Chile ; 146(6): 717-726, jun. 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-961452
ABSTRACT

Background:

Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity.

Aim:

To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and

Methods:

409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio.

Results:

A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI) 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score.

Conclusions:

This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Adiposity / Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Genotype / Obesity Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Chile / Colombia / United kingdom Institution/Affiliation country: Universidad Austral de Chile/CL / Universidad Católica de la Santísima Concepción/CL / Universidad San Sebastián/CL / Universidad Santo Tomás/CL / Universidad de Chile/CL / Universidad de Concepción/CL / Universidad del Rosario/CO / University of Glasgow/GB

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Full text: Available Index: LILACS (Americas) Main subject: Adiposity / Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Genotype / Obesity Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Chile / Colombia / United kingdom Institution/Affiliation country: Universidad Austral de Chile/CL / Universidad Católica de la Santísima Concepción/CL / Universidad San Sebastián/CL / Universidad Santo Tomás/CL / Universidad de Chile/CL / Universidad de Concepción/CL / Universidad del Rosario/CO / University of Glasgow/GB