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El polimorfismo rs12979860 C> T en el gen Interferón lambda 4 no está asociado a riesgo de fibrosis hepática en pacientes chilenos con hepatitis crónica por virus C / Interferon Lambda 4 RS12979860 C> T polymorphism is not associated with liver fibrosis in patients with hepatitis C
Brahm, Javier; Urzúa, Alvaro; Poniachik, Jaime; Cáceres, Dante D; Carreño, Laura; Venegas, Mauricio.
  • Brahm, Javier; Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología. Santiago. CL
  • Urzúa, Alvaro; Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología. Santiago. CL
  • Poniachik, Jaime; Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología. Santiago. CL
  • Cáceres, Dante D; Universidad de Chile. Escuela de Salud Pública. Facultad de Medicina. Santiago. CL
  • Carreño, Laura; Hospital Clínico Universidad de Chile. Departamento de Anatomía Patológica. Santiago. CL
  • Venegas, Mauricio; Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología. Santiago. CL
Rev. méd. Chile ; 146(7): 823-829, jul. 2018. tab
Article in Spanish | LILACS | ID: biblio-961467
ABSTRACT
Background. Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory.

Aim:

To evaluate the impact of IFNL4 rs12979860 polymorphism on the risk of fibrosis in patients with CHC. Material and

Methods:

One hundred fifty patients with CHC aged 50 ± 11 years (89 females) were genotyped for IFNL4 rs12979860 using real time PCR. Fibrosis present in liver biopsies was assessed using the METAVIR score, comparing patients with either no fibrosis, mild fibrosis, or intermediate fibrosis (F0+F1+F2, n = 96), with patients with severe fibrosis or cirrhosis (F3+F4, n = 54).

Results:

In F0-F2 patients the distribution of rs12979860 genotypes was 22 CC, 57 CT and 17 TT, whereas in patients F3-F4 the distribution was 10, 29 and 15, respectively. No association between IFNL4 rs12979860 genotype and risk of fibrosis was observed in uni or multivariate analyses.

Conclusions:

IFNL4 rs12979860 C>T polymorphism is not associated with risk of liver fibrosis in this group of patients with CHC.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Interleukins / Hepatitis C, Chronic / Liver Cirrhosis Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital Clínico Universidad de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Interleukins / Hepatitis C, Chronic / Liver Cirrhosis Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2018 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital Clínico Universidad de Chile/CL