Efecto de la metformina en la etapa de inducción en pacientes con leucemia aguda linfoblástica y su impacto clínico en la supervivencia / Effect of metformin added to chemotherapy on the survival of patients with acute lymphoblastic leukemia
Rev. méd. Chile
;
146(7): 846-853, jul. 2018. tab, graf
Article
in Spanish
| LILACS
| ID: biblio-961470
ABSTRACT
Background:
Metformin has antineoplastic and cancer protective effects in vitro, sensitizing leukemia cells to chemotherapeutic agents, inducing apoptosis and cell cycle arrest.Aim:
To assess the effect of metformin on the induction stage in patients with ALL and its impact on overall survival and relapse. Material and Methods. We included 123 patients treated with metformin and without metformin. The dose used was 850 mg PO at 8 h intervals. The survival analysis was used by Kaplan-Meier method, the difference between the distinct groups was performed using the log Rank test. Results. The overall survival at a median follow up of 700 days of follow-up was 43%, with a disease-free survival of 47%. Regarding the treatment groups, patients with metformin had a lower rate of relapse compared to the group receiving only chemotherapy (6.5% vs 17.1%, p = 0.006). Conclusions. The addition of metformin to the conventional treatment of ALL was associated with an improvement in survival, this association being independent of the type of biological risk at diagnosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Metformin
Type of study:
Etiology study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Hospital General de México "Dr. Eduardo Liceaga"/MX
/
Secretaria de Salud/MX
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