Síndrome de Vogt-Koyanagi-Harada en niños / Vogt-Koyanagi-Harada syndrome in children
Rev. Hosp. Clin. Univ. Chile
; 28(3): 181-188, 20170000. tab
Article
in Es
| LILACS
| ID: biblio-970216
Responsible library:
CL36.1
ABSTRACT
Vogt-Koyanagi-Harada (VKH) syndrome is a systemic inflammatory disease that causes chronic and bilateral granulomatous panuveitis, usually described in adults. Objectives:
To describe manifestations and complications of VKH in pediatric patients.Methods:
Retrospectivedescriptive study upon patients <14 years-old with VKH, attended from January 1985 to July 2010 in three different centers.Results:
A total of 17 patients (34 eyes) were studied; 9 (53%) female. The mean age was 10.8 years-old. Among extraocular manifestations; neurological (71%), dermatological (29%) and auditive (24%) signs were observed. Ocular findings included optic-disc involvement (94%), anterior uveitis (79%), choroiditis (77%), serous retinal detachment (71%) and vitritis (71%). Initial visual acuity (VA) was ≤0.05 in 47% of cases and ≥0.6 in 12% of patients. 71% presented complications glaucoma (20 eyes), sinechiae (10 eyes), maculopathy (6 eyes) cataract (5 eyes) and ptisis bulbi (1 eyes). 35% received only corticosteroids and 65% inmunosupressive drugs. After treatment, 6% had VA ≤0.05 and 59% ≥0.6. Ten patients (59%) recurred 30% compromising posterior pole, and 50% recurred >3 times.Conclusions:
VKH in children is infrequent. It presents with optic-disc involvement and complications of posterior pole. It requires a high degree of suspicion, quick evaluation and early treatment, which include inmunosupressive and extended corticosteroid therapy. Nevertheless, a high rate of recurrence is seen among this group of patients. (AU)
Full text:
1
Index:
LILACS
Main subject:
Uveomeningoencephalitic Syndrome
Type of study:
Observational_studies
Limits:
Adolescent
/
Child
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Child, preschool
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Female
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Humans
/
Male
Language:
Es
Journal:
Rev. Hosp. Clin. Univ. Chile
/
Revista Hospital Clinico Universidad de Chile
Journal subject:
MEDICINA
Year:
2017
Type:
Article