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Papel da via S100B/RAGE/NFkB na patogênese da mucosite intestinal experimental por 5-fluorouracil desregulação de células gliais e de neurônios entéricos
Fortaleza; s.n; 2016. 155 p. ilus, tab.
Thesis in Portuguese | LILACS | ID: biblio-971908
ABSTRACT
5-Fluorouracil (5-FU) promotesintestinal mucositis and motility alterations. Themucositis affect about40% of patients receiving 5-FU and there arereports of patients presentingmucositis afterthe first dose. Under other inflammatory conditions, the S100βprotein is involved in the RAGE activation with subsequent NFκBtranslocation to the nucleus and transcription of TNF-αand iNOS. The enteric glial cells through several mediators, such asS100β, interact with the intestinal epithelial cells and enteric neurons. Therefore, the aim of this study was investigatethe effect of 5-FU in the enteric glial cells and neurons, as well as studythe role of the via S100β/RAGE/NFκB in the pathogenesis of the experimental intestinal mucositis. Swiss male mice received saline (control, 0.9%, i.p.) or5-FU (450 mg/Kg, i.p., single dose). After24h, mice weretreated with pentamidine, aS100 βinhibitor (P0.8 mg/Kg +5FU; P4 mg/Kg +5FU; or onlyP4mg/Kg, i.p.) during two days and euthanized on the fouth day of the experimental protocol...
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Full text: Available Index: LILACS (Americas) Main subject: Neuroglia / Enteric Nervous System / Mucositis / Fluorouracil / Neurons Type of study: Etiology study / Practice guideline Limits: Humans Language: Portuguese Year: 2016 Type: Thesis

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Full text: Available Index: LILACS (Americas) Main subject: Neuroglia / Enteric Nervous System / Mucositis / Fluorouracil / Neurons Type of study: Etiology study / Practice guideline Limits: Humans Language: Portuguese Year: 2016 Type: Thesis