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Association of interleukin-10 -592a>c and -819t>c polymorphisms with gastric cancer risk: a systematic review and meta-analysis of 44 case-control studies / Associação de polimorfismos da interleucina-10 -592 a>c e -819 t> c com risco de câncer gástrico: revisão sistemática e metanálise de 44 estudos de caso-controle
Moghmi, Mansour; Arjmandi, Amir; Aghili, Kazem; Jafari, Mohammadali; Zare-Shehneh, Masoud; Rastegar, Shohreh; Abolbaghel, Seyed Mojtaba; Neamatzadeh, Hossein.
  • Moghmi, Mansour; Shahid Sadoughi University of Medical Sciences. Yazd. IR
  • Arjmandi, Amir; Shahid Sadoughi University of Medical Sciences. Yazd. IR
  • Aghili, Kazem; Shahid Sadoughi University of Medical Sciences. Yazd. IR
  • Jafari, Mohammadali; Shahid Sadoughi University of Medical Sciences. Yazd. IR
  • Zare-Shehneh, Masoud; Shahid Sadoughi University of Medical Sciences. Yazd. IR
  • Rastegar, Shohreh; Shahid Sadoughi University of Medical Sciences. Yazd. IR
  • Abolbaghel, Seyed Mojtaba; Shahid Beheshti University of Medical Sciences. Tehran. IR
  • Neamatzadeh, Hossein; Shahid Sadoughi University of Medical Sciences. Yazd. IR
ABCD (São Paulo, Impr.) ; 32(1): e1415, 2019. tab, graf
Article in English | LILACS | ID: biblio-973380
ABSTRACT
ABSTRACT

Introduction:

A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive.

Objective:

To better understand the association of the polymorphisms with GC risk, we performed a comprehensive meta-analysis.

Method:

An electronic search was performed of several databases to identify relevant studies up to April 2018.

Results:

A total of 44 case-control studies, including 26 studies on IL-10 -592A>C (5,332 cases and 8,272 controls) and 18 studies on IL-10 -819T>C (3,431 cases and 6,109 controls) were selected. Overall, -592A>C polymorphism was associated with the risk of GC under the heterozygote model (OR=1.153, 95% CI=1.020-1.305, p=0.023), but not -819T>C polymorphism. When stratified by ethnicity, significant association was only observed in the Asians under the allele model (OR=1.153, 95% CI=1.007-1.320, p=0.040) and the heterozygote model (OR=1.218, 95% CI=1.076-1.379, p=0.002) for -592A>C.

Conclusion:

The current meta-analysis results inconsistent with previous meta-analyses; showed that the IL-10 -592A>C polymorphism, but not -819T>C polymorphism, may be contributed to the susceptibility of GC in overall and Asian populations.
RESUMO
RESUMO

Introdução:

Uma série de estudos avaliou a associação entre os polimorfismos -592A>C e -819T>C nas regiões promotoras do risco de interleucina-10 (IL-10) e câncer gástrico (GC). No entanto, os resultados permanecem inconclusivos.

Objetivo:

Para entender melhor a associação dos polimorfismos com o risco de GC, realizamos uma meta-análise abrangente.

Método:

Foi realizada busca eletrônica de vários bancos de dados para identificar estudos relevantes até abril de 2018.

Resultados:

Um total de 44 estudos caso-controle, incluindo 26 estudos sobre IL-10 -592A>C (5.332 casos e 8.272 controles) e 18 estudos sobre IL-10 -819T>C (3.431 casos e 6.109 controles) foram selecionados. No geral, o polimorfismo -592A> C foi associado ao risco de GC sob o modelo heterozigoto (OR=1,153, 95% IC=1,020-1,305, p=0,023), mas não polimorfismo -819T>C. Quando estratificada por etnia, associação significativa foi observada apenas nos asiáticos sob o modelo alelo (OR=1,153, IC 95%=1,007-1,320, p=0,040) e o modelo heterozigoto (OR=1,218, IC 95%=1,076-1,379, p=0,002) para -592A>C.

Conclusão:

Os atuais resultados são inconsistentes com metanálises anteriores; mostrou que o polimorfismo IL-10 -592A> C, mas não o polimorfismo -819T>C, pode ter contribuído para a suscetibilidade de GC em populações globais e asiáticas.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Stomach Neoplasms / Interleukin-10 / Risk Assessment Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: ABCD (São Paulo, Impr.) Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Shahid Beheshti University of Medical Sciences/IR / Shahid Sadoughi University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Stomach Neoplasms / Interleukin-10 / Risk Assessment Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: ABCD (São Paulo, Impr.) Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Shahid Beheshti University of Medical Sciences/IR / Shahid Sadoughi University of Medical Sciences/IR