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Vascular and ventilatory mechanical responses in three different stages of pulmonary development in the rabbit model of congenital diaphragmatic hernia
Figueira, Rebeca Lopes; Costa, Karina Miura da; Marsico, Ana Laura; Milani, Thamires Melchiades da Silva; Gonçalves, Walusa Assad; Borges, Marcos de Carvalho; Silva, Orlando Castro e; Sbragia, Lourenço.
  • Figueira, Rebeca Lopes; Universidade de São Paulo. Ribeirao Preto Medical School. Department of Surgery and Anatomy. Ribeirao Preto. BR
  • Costa, Karina Miura da; USP. Ribeirao Preto Medical School. Department of Surgery and Anatomy. Ribeirao Preto. BR
  • Marsico, Ana Laura; USP. Ribeirao Preto Medical School. Department of Surgery and Anatomy. Ribeirao Preto. BR
  • Milani, Thamires Melchiades da Silva; USP. Ribeirao Preto Medical School. Department of Internal Medicine. Ribeirao Preto. BR
  • Gonçalves, Walusa Assad; USP. Ribeirao Preto Medical School. Department of Pediatrics. Ribeirao Preto. BR
  • Borges, Marcos de Carvalho; USP. Ribeirao Preto Medical School. Department of Internal Medicine. Ribeirao Preto. BR
  • Silva, Orlando Castro e; USP. Ribeirao Preto Medical School. Department of Surgery and Anatomy. Ribeirao Preto. BR
  • Sbragia, Lourenço; USP. Ribeirao Preto Medical School. Department of Surgery and Anatomy. Ribeirao Preto. BR
Acta cir. bras ; 33(10): 879-888, Oct. 2018. graf
Article in English | LILACS | ID: biblio-973464
ABSTRACT
Abstract

Purpose:

To evaluate the vascular ventilatory response in different stages of lung development and to compare them to the neonates with congenital diaphragmatic hernia (CDH) in a rabbit model.

Methods:

New Zealand rabbits were divided into 8 groups (n=5) E25, E27, E30, and CDH. All groups were ventilated on a FlexiVent (Scireq, Montreal, QC, Canada), compounding the other 4 groups. The CDH surgery was performed at E25 and the harvest at E30. Dynamic compliance (CRS), dynamic elastance (ERS) and dynamic resistance (RRS) were measured every 4 min/24 min. Median wall thickness (MWT) and airspace were measured. ANOVA Bonferroni tests were used to perform statistical analysis. Significance was considered when p<0.05.

Results:

CRS was higher in E30 compared to all other groups (p<0.05). CRS and RRS of CDH and E27 were similar and were higher in E25 (p<0.05). MWT was decreased according to the gestational age, was increased in E27V and E30V (p<0.05) and decreased in CDHV (p<0.05), airspace was decreased in E25 and increased in all ventilated groups (p<0.05).

Conclusions:

The ventilation response of congenital diaphragmatic hernia is like the pseudoglandular stage of the lung development. These findings add information about the physiology of pulmonary ventilation in CDH.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Respiratory Mechanics / Hernias, Diaphragmatic, Congenital / Lung Type of study: Etiology study / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: USP/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Respiratory Mechanics / Hernias, Diaphragmatic, Congenital / Lung Type of study: Etiology study / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: USP/BR / Universidade de São Paulo/BR