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Influence of tramadol on functional recovery of acute spinal cord injury in rats
Chaves, Rosa Helena de Figueiredo; Souza, Celice Cordeiro de; Furlaneto, Ismari Perini; Teixeira, Renan Kleber Costa; Oliveira, Carolina Pinheiro de; Rodrigues, Emanuelle de Matos; Santos, Daniel Arthur Santos dos; Silva, Renata Cunha; Penha, Nelson Elias Abrahão da; Lima, Ana Rita de.
  • Chaves, Rosa Helena de Figueiredo; Universidade Federal Rural da Amazônia. Postgraduate Program in Health and Animal Production in Amazon. Belem. BR
  • Souza, Celice Cordeiro de; Centro Universitário do Estado do Pará. School of Medicine. Belem. BR
  • Furlaneto, Ismari Perini; Universidade Federal do Pará. Postgraduate Program in Parasitic Biology at Amazon. Belem. BR
  • Teixeira, Renan Kleber Costa; Universidade do Estado do Pará. School of Medicine. Department of Experimental Surgery. Belem. BR
  • Oliveira, Carolina Pinheiro de; CESUPA. School of Medicine. Belem. BR
  • Rodrigues, Emanuelle de Matos; CESUPA. School of Medicine. Belem. BR
  • Santos, Daniel Arthur Santos dos; CESUPA. School of Medicine. Belem. BR
  • Silva, Renata Cunha; UEPA. School of Occupational Therapy. Belem. BR
  • Penha, Nelson Elias Abrahão da; CESUPA. School of Medicine. Belem. BR
  • Lima, Ana Rita de; UFRA. Institute of Health and Animal Production. Belem. BR
Acta cir. bras ; 33(12): 1087-1094, Dec. 2018. tab, graf
Article in English | LILACS | ID: biblio-973483
ABSTRACT
Abstract

Purpose:

To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats.

Methods:

Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn't receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods.

Results:

There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group.

Conclusion:

The tramadol as an analgesic agent don't influence on functional recovery of acute spinal cord injury in rats
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Full text: Available Index: LILACS (Americas) Main subject: Spinal Cord Injuries / Tramadol / Recovery of Function / Analgesics, Opioid Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: CESUPA/BR / Centro Universitário do Estado do Pará/BR / UEPA/BR / UFRA/BR / Universidade Federal Rural da Amazônia/BR / Universidade Federal do Pará/BR / Universidade do Estado do Pará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Spinal Cord Injuries / Tramadol / Recovery of Function / Analgesics, Opioid Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: CESUPA/BR / Centro Universitário do Estado do Pará/BR / UEPA/BR / UFRA/BR / Universidade Federal Rural da Amazônia/BR / Universidade Federal do Pará/BR / Universidade do Estado do Pará/BR